Testing Data
MCP-5 active protein
Murine MCP-5 (CCL12)
Cross Reactivity: Human
Cross Reactivity: Human
Testing Data
Testing Data
NCBI and Uniprot Product Information
Uniprot Description
CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted
Cellular Component: extracellular space; extracellular region; intracellular
Molecular Function: chemokine activity; CCR2 chemokine receptor binding; cytokine activity
Biological Process: cytokine and chemokine mediated signaling pathway; positive regulation of leukocyte migration; MAPKKK cascade; cytoskeleton organization and biogenesis; chemotaxis; macrophage chemotaxis; regulation of cell shape; monocyte chemotaxis; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; immune response; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; astrocyte cell migration
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Product Notes
The MCP-5 ccl12 (Catalog #AAA695754) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Murine MCP-5 (CCL12) reacts with Species Reactivity: Mouse Cross Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GPDAVSTPV TCCYNVVKQ KIHVRKLKS YRRITSSQC PREAVIFRT ILDKEICAD PKEKWVKNS INHLDKTSQ TFILEPSCL G. It is sometimes possible for the material contained within the vial of "MCP-5, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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