IL-31 active protein

Recombinant Human IL-31 Protein

Cat. Num. AAA9139841

• Gene Names: IL31; IL-31
• Purity: >95% by SDS-PAGE.
• Synonyms: IL-31; Recombinant Human IL-31 Protein; IL-31 active protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
• Sequence: SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
• Sequence Length: 164

• Species: Human
• Endotoxin: < 1 EU/ug of the protein by LAL method.
• Biological Activity: Measured by inducing STAT3 activation in U87 MG human glioblastoma/astrocytoma cells. The ED50 for this effect is typically 5 ng/mL.
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
• Tag: No tag
• Preparation and Storage: Store the lyophilized protein at -20 degree C to -80 degree C for long term.; After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.

SDS-Page

(Recombinant protein Human IL-31 was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 16 kDa.)

Related Product Information for IL-31 active protein

Recombinant Human IL-31 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser24-Thr164) of human IL-31 (Accession #Q6EBC2).

Product Categories/Family for IL-31 active protein

Cytokines & Cytokine Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 62122911
• NCBI GeneID: 386653
• NCBI Accession #: NP_001014358.1
• NCBI GenBank Nucleotide #: NP_001014358.1
• UniProt Accession #: Q6EBC2
• NCBI Official Full Name: interleukin-31
• NCBI Official Synonym Full Names: interleukin 31
• NCBI Official Symbol: IL31
• NCBI Official Synonym Symbols: IL-31
• NCBI Protein Information: interleukin-31
• UniProt Protein Name: Interleukin-31
• UniProt Gene Name: IL31
• UniProt Synonym Gene Names: IL-31
• UniProt Entry Name: IL31_HUMAN

NCBI Description

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

Uniprot Description

IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: immune system process