CD74 protein Active Protein | CD74 active protein

Recombinant Mouse CD74 protein (His Tag)

Cat. Num. AAA2569380

• Gene Names: Cd74; Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: CD74 protein; Recombinant Mouse CD74 protein (His Tag); CD 74; CD74; CD74 antigen (invariant polypeptide of major histocompatibility complex; class II antigen-associated); CD74 antigen; CD74 molecule; major histocompatibility complex; class II invariant chain; CLIP; DHLAG; Gamma chain of class II antigens; HG2A; HLA class II histocompatibility antigen gamma chain; HLA DR antigens associated invariant chain; HLA DR gamma; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; HLADG; HLADR antigens associated invariant chain; Ia antigen associated invariant chain; Ia antigen-associated invariant chain; Ia associated invariant chain; Ia gamma; Ii; Invariant polypeptide of major histocompatibility complex class II antigen associated; la-gamma; Major histocompatibility complex class II invariant chain; MHC HLA DR gamma chain; MHC HLA-DR gamma chain; p33; p35; Protein 41; CD74 active protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: 56Q-279L

• Species: Mouse
• Tag: N/C-His
• Protein Construction: A DNA sequence encoding theMouse CD74 protein (P04441)(56Q-279L) was expressed with a polyhistidine tag at the N-terminus.
• Activity: Immunogen (E-AB-40348)
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for CD74 active protein

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.

NCBI and Uniprot Product Information

• NCBI GI #: 110624770
• NCBI GeneID: 16149
• NCBI Accession #: NP_001036070.1
• NCBI GenBank Nucleotide #: NM_001042605.1
• UniProt Accession #: P04441; O19452
• Molecular Weight: 31,557 Da
• NCBI Official Full Name: H-2 class II histocompatibility antigen gamma chain isoform 1
• NCBI Official Synonym Full Names: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
• NCBI Official Symbol: Cd74
• NCBI Official Synonym Symbols: Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
• NCBI Protein Information: H-2 class II histocompatibility antigen gamma chain; HLA-DR-GAMMA; dinucleotide microsatellite; Ia-associated invariant chain; ia antigen-associated invariant chain; MHC class II-associated invariant chain; class II-associated invariant chain peptide; his
• UniProt Protein Name: H-2 class II histocompatibility antigen gamma chain
• Protein Family: H-2 class II histocompatibility antigen
• UniProt Gene Name: Cd74
• UniProt Synonym Gene Names: Ii; Ii
• UniProt Entry Name: HG2A_MOUSE

Uniprot Description

CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine; Endoplasmic reticulum

Cellular Component: Golgi apparatus; multivesicular body; cell surface; membrane; integral to plasma membrane; lysosome; endoplasmic reticulum; late endosome; plasma membrane; integral to membrane; vacuole; intracellular; external side of plasma membrane; MHC class II protein complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; beta-amyloid binding; cytokine binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; MHC class II protein binding

Biological Process: protein folding; activation of MAPK activity; positive regulation of dendritic cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; defense response; prostaglandin biosynthetic process; signal transduction; negative regulation of T cell differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; intracellular protein transport; positive regulation of fibroblast proliferation; negative regulation of mature B cell apoptosis; positive regulation of innate immune response; positive regulation of B cell proliferation; protein complex assembly; positive regulation of adaptive immune response; positive thymic T cell selection; negative regulation of peptide secretion; positive regulation of T-helper 2 type immune response; chaperone cofactor-dependent protein folding; immune system process; cytokine and chemokine mediated signaling pathway; negative thymic T cell selection; antigen processing and presentation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; immune response; immunoglobulin mediated immune response; positive regulation of cytokine and chemokine mediated signaling pathway; negative regulation of apoptosis