Rabbit H-2 class II histocompatibility antigen gamma chain Polyclonal Antibody | anti-Cd74 antibody

Rabbit anti-mouse H-2 class II histocompatibility antigen gamma chain polyclonal Antibody

Cat. Num. AAA1489247

• Gene Names: Cd74; Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
• Reactivity: Mouse. Other species are not tested. Please decide the specificity by homology
• Applications: ELISA, Western Blot
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: H-2 class II histocompatibility antigen gamma chain; Polyclonal Antibody; Rabbit anti-mouse H-2 class II histocompatibility antigen gamma chain polyclonal Antibody; a antigen-associated invariant chain MHC class II-associated invariant chain CD_antigen=CD74 Cd74; anti-Cd74 antibody

• Host: Rabbit
• Reactivity: Mouse. Other species are not tested. Please decide the specificity by homology
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 279

• Applicable Applications for anti-Cd74 antibody: ELISA (EIA), Western Blot (WB)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant mouse H-2 class II histocompatibility antigen gamma chain protein
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: H-2 class II histocompatibility antigen gamma chain antibody at 2ug/ml+mouse spleen tissueSecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilutionPredicted band size: 32,25 kDaObserved band size: 34 kDa)

Western Blot (WB)

(Western BlotPositive WB detected in: Mouse brain tissueAll lanes: Cd74 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 32,25 KDaObserved band size: 32 KDa)

Related Product Information for anti-Cd74 antibody

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

NCBI and Uniprot Product Information

• NCBI GI #: 110624770
• NCBI GeneID: 16149
• NCBI Accession #: NP_001036070.1
• NCBI GenBank Nucleotide #: NM_001042605.1
• UniProt Accession #: P04441; O19452
• Molecular Weight: 24,454 Da
• NCBI Official Full Name: H-2 class II histocompatibility antigen gamma chain isoform 1
• NCBI Official Synonym Full Names: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
• NCBI Official Symbol: Cd74
• NCBI Official Synonym Symbols: Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
• NCBI Protein Information: H-2 class II histocompatibility antigen gamma chain
• UniProt Protein Name: H-2 class II histocompatibility antigen gamma chain
• Protein Family: H-2 class II histocompatibility antigen
• UniProt Gene Name: Cd74
• UniProt Synonym Gene Names: Ii; Ii
• UniProt Entry Name: HG2A_MOUSE

Uniprot Description

CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; integral to plasma membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuole

Molecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; protein binding

Biological Process: activation of MAPK activity; adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immune response; immune system process; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of adaptive immune response; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of innate immune response; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction