D(4) dopamine receptor (DRD4) Recombinant Protein | DRD4 recombinant protein
Recombinant Human D (4) dopamine receptor (DRD4)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
Uniprot Description
DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cell cortex; cell soma; dendritic spine; integral to plasma membrane; membrane; plasma membrane; terminal button; vesicle membrane
Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; potassium channel regulator activity; protein binding; SH3 domain binding
Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral fear response; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; circadian rhythm; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; olfactory learning; photoperiodism; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of calcium-mediated signaling; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; regulation of neurotransmitter secretion; response to amphetamine; response to steroid hormone stimulus; retina development in camera-type eye; short-term memory; social behavior; synaptic transmission, dopaminergic
Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait
Research Articles on DRD4
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Product Notes
The DRD4 drd4 (Catalog #AAA7013907) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-419aa; Full Length. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the DRD4 drd4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGNRSTADAD GLLAGRGPAA GASAGASAGL AGQGAAALVG GVLLIGAVLA GNSLVCVSVA TERALQTPTN SFIVSLAAAD LLLALLVLPL FVYSEVQGGA WLLSPRLCDA LMAMDVMLCT ASIFNLCAIS VDRFVAVAVP LRYNRQGGSR RQLLLIGATW LLSAAVAAPV LCGLNDVRGR DPAVCRLEDR DYVVYSSVCS FFLPCPLMLL LYWATFRGLQ RWEVARRAKL HGRAPRRPSG PGPPSPTPPA PRLPQDPCGP DCAPPAPGLP RGPCGPDCAP AAPSLPQDPC GPDCAPPAPG LPPDPCGSNC APPDAVRAAA LPPQTPPQTR RRRRAKITGR ERKAMRVLPV VVGAFLLCWT PFFVVHITQA LCPACSVPPR LVSAVTWLGY VNSALNPVIY TVFNAEFRNV FRKALRACC . It is sometimes possible for the material contained within the vial of "D(4) dopamine receptor (DRD4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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