Trp63 blocking peptide
Trp63 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Uniprot Description
p63: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Belongs to the p53 family. 12 isoforms of the human protein are produced by alternative promoter.
Protein type: DNA-binding; Transcription factor
Cellular Component: chromatin; cytoplasm; cytosol; dendrite; neuron projection; nuclear chromatin; nucleoplasm; nucleus; protein complex; rough endoplasmic reticulum; transcription factor complex
Molecular Function: chromatin binding; damaged DNA binding; DNA binding; double-stranded DNA binding; identical protein binding; metal ion binding; p53 binding; protein binding; protein domain specific binding; sequence-specific DNA binding; transcription factor activity; WW domain binding
Biological Process: anatomical structure formation; apoptosis; cell aging; cell differentiation; chromatin remodeling; cloacal septation; developmental process; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; ectoderm and mesoderm interaction; embryonic limb morphogenesis; epidermal cell division; epidermis development; epithelial cell development; epithelial cell differentiation; establishment of planar polarity; female genitalia morphogenesis; G1 DNA damage checkpoint; hair follicle development; hair follicle morphogenesis; keratinocyte differentiation; keratinocyte proliferation; morphogenesis of a polarized epithelium; multicellular organismal aging; multicellular organismal development; negative regulation of apoptosis; negative regulation of keratinocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron apoptosis; Notch signaling pathway; odontogenesis of dentine-containing teeth; organ morphogenesis; pattern specification process; polarized epithelial cell differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein homotetramerization; protein tetramerization; proximal/distal pattern formation; regulation of caspase activity; regulation of epidermal cell division; regulation of neuron apoptosis; regulation of transcription, DNA-dependent; replicative cell aging; response to DNA damage stimulus; response to gamma radiation; response to X-ray; skeletal development; skin morphogenesis; smooth muscle development; sympathetic nervous system development; transcription, DNA-dependent; urinary bladder development
Research Articles on Trp63
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Product Notes
The Trp63 tp63 (Catalog #AAA427927) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The Trp63 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ENNAQTQFSE PQYC. It is sometimes possible for the material contained within the vial of "Trp63, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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