Chromosome 6 Open Reading Frame 108 Recombinant Protein | C6ORF108 recombinant protein

Recombinant Human Chromosome 6 Open Reading Frame 108

Cat. Num. AAA144119

• Gene Names: DNPH1; RCL; C6orf108; dJ330M21.3
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Chromosome 6 Open Reading Frame 108; Recombinant Human Chromosome 6 Open Reading Frame 108; C6ORF108 Human; Chromosome 6 Open Reading Frame 108 Human Recombinant; c-Myc-responsive protein Rcl; RCL; putative c-Myc-responsive; C6ORF108 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The C6ORF108 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH-8), 1mM DTT, and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MAAAMVPGRS ESWERGEPGR PALYFCGSIR GGREDRTLYE RIVSRLRRFG TVLTEHVAAA ELGARGEEAAGGDRLIHEQD LEWLQQADVV VAEVTQPSLG VGYELGRAVA FNKRILCLFR PQSGRVLSAM IRGAADGSRF QVWDYEEGEV EALLDRYFEA DPPGQVAASP DPTT
• Sequence Length: 174

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for C6ORF108 recombinant protein

Description: C6ORF108 produced in E Coli is a single, non-glycosylated polypeptide chain containing 194 amino acids (1-174 a.a.) and having a molecular mass of 21.2kDa.C6ORF108 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: C6ORF108 is stimulated by c-Myc protein that is a transcription factor that is involved in the regulation of cell proliferation, differentiation, and apoptosis. C6ORF108 functions in rat in cellular proliferation and c-Myc-mediated transformation. C6ORF108 catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5''-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5''-monophosphates comprising purine bases are favored to those comprising of pyrimidine bases.

Product Categories/Family for C6ORF108 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Chromosome Open Reading Frame

NCBI and Uniprot Product Information

• NCBI GI #: 5454002
• NCBI GeneID: 10591
• NCBI Accession #: NP_006434.1
• NCBI GenBank Nucleotide #: NM_006443.2
• UniProt Accession #: O43598; B2LUJ9
• Molecular Weight: 16,187 Da
• NCBI Official Full Name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 1
• NCBI Official Synonym Full Names: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
• NCBI Official Symbol: DNPH1
• NCBI Official Synonym Symbols: RCL; C6orf108; dJ330M21.3
• NCBI Protein Information: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; DNPH1; c-Myc-responsive protein RCL; c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase; putative c-Myc-responsive
• UniProt Protein Name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
• UniProt Gene Name: DNPH1
• UniProt Entry Name: DNPH1_HUMAN

NCBI Description

This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

DNPH1: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. Monomer and homodimer. Expression is induced by ETV1. Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. Belongs to the deoxyribonucleoside 5'-monophosphate N- glycosidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.2.-; Hydrolase

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein homodimerization activity; nucleoside deoxyribosyltransferase activity

Biological Process: cell proliferation; epithelial cell differentiation; nucleoside metabolic process; nucleotide metabolic process; positive regulation of cell growth; deoxyribonucleoside monophosphate catabolic process