Human discs, large (Drosophila) homolog-associated protein 5 ELISA Kit | DLGAP5 elisa kit

Human Disks large-associated protein 5, DLGAP5 ELISA Kit

Cat. Num. AAA9338169

• Gene Names: DLGAP5; DLG7; HURP
• Reactivity: Human
• Synonyms: discs; large (Drosophila) homolog-associated protein 5; Human Disks large-associated protein 5; DLGAP5 ELISA Kit; Human Disks large-associated protein 5 (DLGAP5) ELISA kit; DLG7; HURP; KIAA0008; Drosophila discs large-1 tumor suppressor-like; discs large homolog 7; large homolog 7; hepatoma up-regulated protein; DLGAP5 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 226371669
• NCBI GeneID: 9787
• NCBI Accession #: NP_001139487.1
• NCBI GenBank Nucleotide #: NM_001146015.1
• UniProt Accession #: Q15398; Q86T11; Q8NG58; A8MTM6; B4DRM8
• Molecular Weight: 95,115 Da
• NCBI Official Full Name: disks large-associated protein 5 isoform b
• NCBI Official Synonym Full Names: discs, large (Drosophila) homolog-associated protein 5
• NCBI Official Symbol: DLGAP5
• NCBI Official Synonym Symbols: DLG7; HURP
• NCBI Protein Information: disks large-associated protein 5; DAP-5; discs large homolog 7; discs, large homolog 7; hepatoma up-regulated protein; disks large-associated protein DLG7
• UniProt Protein Name: Disks large-associated protein 5
• Protein Family: Disks large-associated protein
• UniProt Gene Name: DLGAP5
• UniProt Synonym Gene Names: DLG7; KIAA0008; DAP-5; HURP
• UniProt Entry Name: DLGP5_HUMAN

Uniprot Description

DLG7: a cell cycle regulator that may play a role in carcinogenesis. Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. Required for chromosome congression and alignment. Stabilizes mitotic microtubules, promotes microtubule polymerization and controls spindle formation and dynamics Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Interacts with CDC2 and localizes to the spindle poles in mitotic cells. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Colocalizes with E-cadherin (CDH1) at sites of cell-cell contact in intestinal epithelial cells. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Two alternatively spliced isoforms have been described.

Protein type: Microtubule-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: cytoplasm; microtubule organizing center; spindle pole centrosome; nucleus

Molecular Function: protein binding; phosphoprotein phosphatase activity

Biological Process: cell proliferation; cell-cell signaling; dephosphorylation; positive regulation of mitotic metaphase/anaphase transition; mitotic chromosome movement towards spindle pole