Type III iodothyronine deiodinase (dio3) Recombinant Protein | dio3 recombinant protein
Recombinant Xenopus laevis Type III iodothyronine deiodinase (dio3), partial
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. As in other verterbrates, studies in xenopus show that this enzyme is involved in early embryonic development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. A homeolog of this gene is found on chromosome 8S. [provided by RefSeq, Jul 2017]
Uniprot Description
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). May play a protective role in selected tissues by preventing their exposure to inappropriately timed or excessive levels of thyroid hormone.
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Product Notes
The dio3 dio3 (Catalog #AAA1172052) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 37-271.(U132S) Partial, provide the complete extracellular domain. The amino acid sequence is listed below: DFQCIRRRVL LTAREESTAE HEDPPLCVSD SNRMCTVESL RAVWHGQKLD YFKSAHLGCS APNTEVVMLE GRRLCKILDF SQGKRPLVVN FGSCTSPPFM ARLQAYRRLA AQHVGIADFL LVYIEEAHPS DGWLSTDASY QIPQHQCLQD RLAAAQLMLQ GAPGCRVVVD TMDNSSNAAY GAYFERLYIV LEGKVVYQGG RGPEGYKISE LRMWLEQYQQ GLMGTKGSGQ VVIQV. It is sometimes possible for the material contained within the vial of "Type III iodothyronine deiodinase (dio3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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