GRO Beta/CXCL2 Recombinant Protein | CXCL2 recombinant protein

GRO Beta/CXCL2 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122517

• Gene Names: Cxcl2; GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a
• Purity: >95% as determined by SDS-PAGE
• Synonyms: GRO Beta/CXCL2; GRO Beta/CXCL2 Protein; Mouse; Recombinant (His Tag); Mouse CXCL2/MIP-2 Protein (His Tag); CINC-2a Protein; Gro2 Protein; GROb Protein; Mgsa-b Protein; MIP-2 Protein; MIP-2a Protein; Mip2 Protein; Scyb Protein; Scyb2 Protein; chemokine (C-X-C motif) ligand 2; CXCL2 recombinant protein

• Host: Yeast
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 30% CAN. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ala28-Asn100

• Species: Mouse
• Predicted N Terminal: Ala 28
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse Cxcl2 (NP_033166.1)(Ala28-Asn100) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for CXCL2 recombinant protein

Background: Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.

Product Categories/Family for CXCL2 recombinant protein

Neuroinflammation; IL17 signaling pathway

References

Driscoll KE. (2000) TNFalpha and MIP-2: role in particle-induced inflammation and regulation by oxidative stress. Toxicol Lett. 112-113: 177-83.Walpen S, et al. (2001) Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. FASEB J. 15(3): 571-3.Fahey TJ, et al. (1990) Cytokine production in a model of wound healing: the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1. Cytokine. 2(2): 92-9.

NCBI and Uniprot Product Information

• NCBI GI #: 6677885
• NCBI GeneID: 20310
• NCBI Accession #: NP_033166.1
• NCBI GenBank Nucleotide #: NM_009140.2
• UniProt Accession #: P10889
• Molecular Weight: 10,621 Da
• NCBI Official Full Name: C-X-C motif chemokine 2
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 2
• NCBI Official Symbol: Cxcl2
• NCBI Official Synonym Symbols: GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a
• NCBI Protein Information: C-X-C motif chemokine 2; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2
• UniProt Protein Name: C-X-C motif chemokine 2
• Protein Family: C-X-C motif chemokine
• UniProt Gene Name: Cxcl2
• UniProt Synonym Gene Names: Mip-2; Mip2; Scyb2; MIP2
• UniProt Entry Name: CXCL2_MOUSE

Uniprot Description

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst.