SDS-Page
CTRL recombinant protein
CTRL Protein, Human, Recombinant (His Tag)
Gene Names
CTRL; CTRL1
Purity
>95% as determined by SDS-PAGE
Synonyms
CTRL; CTRL Protein; Human; Recombinant (His Tag); Human CTRL-1/CTRL/Chymotrypsin-like protease Protein (His Tag); CTRL1 Protein; chymotrypsin-like; CTRL recombinant protein
Host
HEK293 Cells
Purity/Purification
>95% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Asn264
Species
Human
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
Cys 19
Tag
C-His
Protein Construction
A DNA sequence encoding the human CTRL (P40313)(Met1-Asn264) was expressed with a polyhistidine tag at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
SDS-Page
SDS-Page
Related Product Information for CTRL recombinant protein
Background: CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and multiple sclerosis. Five structurally distinct inhibitors that are known to inhibit chymotrypsin-like proteases were partially protective. They might represent a novel class of drugs with benefit in diseases where overactivity of microglia contributes to the pathogenesis.
References
Yang Gu. et al., 2009, Reprod Sci. 16 (9): 905-13. Klegeris A. et al., 2005, Glia. 51 (1):56-64. Caroline V. Bamford. et al., 2007, nfect Immun. 75 (9): 4364-72.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
264
NCBI Official Full Name
Chymotrypsin-like protease CTRL-1
NCBI Official Synonym Full Names
chymotrypsin-like
NCBI Official Symbol
CTRL
NCBI Official Synonym Symbols
CTRL1
NCBI Protein Information
chymotrypsin-like protease CTRL-1
UniProt Protein Name
Chymotrypsin-like protease CTRL-1
Protein Family
UniProt Gene Name
CTRL
UniProt Synonym Gene Names
CTRL1
UniProt Entry Name
CTRL_HUMAN
Uniprot Description
CTRL: Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.-; Protease
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase activity
Biological Process: digestion; proteolysis
Research Articles on CTRL
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Product Notes
The CTRL ctrl (Catalog #AAA8121523) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Asn26 4. It is sometimes possible for the material contained within the vial of "CTRL, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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