ULBP4 Recombinant Protein | RAET1E recombinant protein

ULBP4 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8122028

• Gene Names: RAET1E; RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7
• Purity: >80% as determined by SDS-PAGE
• Synonyms: ULBP4; ULBP4 Protein; Human; Recombinant (His Tag); Human RAET1E/ULBP4 Protein (His Tag); bA350J20.7 Protein; LETAL Protein; N2DL-4 Protein; NKG2DL4 Protein; RAET1E2 Protein; RL-4 Protein; retinoic acid early transcript 1E; RAET1E recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >80% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asp225

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: His 31
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human RAET1E (NP_631904.1)(Met1-Asp225) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for RAET1E recombinant protein

Background: The expressions of both RAET1E2 transcripts and protein can be found in different tumor cells and tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 21040249
• NCBI GeneID: 135250
• NCBI Accession #: NP_631904.1
• NCBI GenBank Nucleotide #: NM_139165.2
• UniProt Accession #: Q8TD07; Q5VYB7; Q5VYB8; Q8TEZ2; Q96L41; A6YF59
• Molecular Weight: 32,300 Da
• NCBI Official Full Name: retinoic acid early transcript 1E isoform 1
• NCBI Official Synonym Full Names: retinoic acid early transcript 1E
• NCBI Official Symbol: RAET1E
• NCBI Official Synonym Symbols: RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7
• NCBI Protein Information: retinoic acid early transcript 1E
• UniProt Protein Name: NKG2D ligand 4
• Protein Family: NKG2D ligand
• UniProt Gene Name: RAET1E
• UniProt Synonym Gene Names: LETAL; N2DL4; ULBP4; N2DL-4; NKG2DL4; RL-4
• UniProt Entry Name: N2DL4_HUMAN

NCBI Description

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Uniprot Description

RAET1E: Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: plasma membrane

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell mediated cytotoxicity; regulation of immune response; T cell mediated cytotoxicity