MEGF10 recombinant protein

MEGF10 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8122021

• Gene Names: MEGF10; EMARDD
• Purity: >90% as determined by SDS-PAGE
• Synonyms: MEGF10; MEGF10 Protein; Human; Recombinant (His Tag); Human MEGF10 Protein (His Tag); EMARDD Protein; multiple EGF-like-domains 10; MEGF10 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly857

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Leu 26
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human MEGF10 (NP_115822.1)(Met1-Gly857) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for MEGF10 recombinant protein

Background: MEGF10 (Multiple EGF Like Domains 10) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility, and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. MEGF10 may also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. It belongs to the MEGF family. Diseases associated with MEGF10 include Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, and Dysphagia.

NCBI and Uniprot Product Information

• NCBI GI #: 14192943
• NCBI GeneID: 84466
• NCBI Accession #: NP_115822.1
• NCBI GenBank Nucleotide #: NM_032446.2
• UniProt Accession #: Q96KG7; Q68DE5; Q8WUL3
• Molecular Weight: 60,797 Da
• NCBI Official Full Name: multiple epidermal growth factor-like domains protein 10 isoform a
• NCBI Official Synonym Full Names: multiple EGF like domains 10
• NCBI Official Symbol: MEGF10
• NCBI Official Synonym Symbols: EMARDD
• NCBI Protein Information: multiple epidermal growth factor-like domains protein 10
• UniProt Protein Name: Multiple epidermal growth factor-like domains protein 10
• Protein Family: Multiple epidermal growth factor-like domains protein
• UniProt Gene Name: MEGF10
• UniProt Synonym Gene Names: KIAA1780; Multiple EGF-like domains protein 10
• UniProt Entry Name: MEG10_HUMAN

NCBI Description

This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]