NDEL1 blocking peptide
NDEL1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]
Uniprot Description
NDEL1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Microtubule-binding
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: axon hillock; centrosome; cytosol; kinesin complex; kinetochore; leading edge; microtubule; neurofilament cytoskeleton; nuclear envelope; spindle; synaptic vesicle
Molecular Function: alpha-tubulin binding; beta-tubulin binding; microtubule binding; protein binding
Biological Process: cell migration; central nervous system neuron axonogenesis; centrosome localization; cerebral cortex radially oriented cell migration; chromosome segregation; establishment of chromosome localization; establishment of mitotic spindle orientation; inner cell mass cell proliferation; microtubule nucleation; mitotic centrosome separation; neurofilament cytoskeleton organization and biogenesis; neuron migration; nuclear envelope disassembly; positive regulation of axon extension; positive regulation of axon regeneration; positive regulation of GTPase activity; proteolysis; regulation of intracellular protein transport; retrograde axon cargo transport; sister chromatid cohesion; vesicle transport along microtubule
Research Articles on NDEL1
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Product Notes
The NDEL1 ndel1 (Catalog #AAA425880) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The NDEL1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: CRNFAKDQAS RKSY. It is sometimes possible for the material contained within the vial of "NDEL1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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