Rabbit NDEL1 Polyclonal Antibody | anti-NDEL1 antibody

NDEL1 Antibody

Cat. Num. AAA2529796

• Gene Names: NDEL1; EOPA; NDE2; NUDEL; MITAP1; NDE1L1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: NDEL1; Polyclonal Antibody; NDEL1 Antibody; EOPA; NDE2; NUDEL; MITAP1; NDE1L1; anti-NDEL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 328

• Applicable Applications for anti-NDEL1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Recombinant protein of human NDEL1
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48063
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using NDEL1 antibody.)

Related Product Information for anti-NDEL1 antibody

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X.

NCBI and Uniprot Product Information

• NCBI GI #: 71284108
• NCBI GeneID: 81565
• NCBI Accession #: NP_001020750.1
• NCBI GenBank Nucleotide #: NM_001025579.2
• Molecular Weight: 37,039 Da
• NCBI Official Full Name: nuclear distribution protein nudE-like 1 isoform A
• NCBI Official Synonym Full Names: nudE neurodevelopment protein 1-like 1
• NCBI Official Symbol: NDEL1
• NCBI Official Synonym Symbols: EOPA; NDE2; NUDEL; MITAP1; NDE1L1
• NCBI Protein Information: nuclear distribution protein nudE-like 1; endooligopeptidase A; mitosin-associated protein 1; mitosin-associated protein MITAP1; nudE nuclear distribution E homolog-like 1; nudE nuclear distribution gene E homolog-like 1; protein Nudel
• UniProt Protein Name: Nuclear distribution protein nudE-like 1
• Protein Family: Nuclear distribution protein
• UniProt Gene Name: NDEL1
• UniProt Synonym Gene Names: EOPA; MITAP1; NUDEL; Protein Nudel
• UniProt Entry Name: NDEL1_HUMAN

NCBI Description

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

Uniprot Description

NDEL1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Protease

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: axon hillock; kinetochore; centrosome; microtubule; kinesin complex; neurofilament cytoskeleton; leading edge; cytoplasm; nucleolus; spindle; nuclear envelope; cytosol

Molecular Function: protein binding; microtubule binding; beta-tubulin binding; alpha-tubulin binding

Biological Process: cell migration; positive regulation of axon regeneration; central nervous system neuron axonogenesis; positive regulation of axon extension; establishment of chromosome localization; neuron migration; nuclear envelope disassembly; microtubule nucleation; proteolysis; inner cell mass cell proliferation; retrograde axon cargo transport; chromosome segregation; mitotic centrosome separation; neurofilament cytoskeleton organization and biogenesis; establishment of mitotic spindle orientation; centrosome localization; vesicle transport along microtubule; cerebral cortex radially oriented cell migration; mitotic cell cycle