FGF-10 active protein

Human FGF-10

Cat. Num. AAA692030

• Reactivity: Human
• Purity: > 95% by SDS-PAGE & silver stain
• Synonyms: FGF-10; Human FGF-10; Recombinant Human Fibroblast Growth Factor-10; Keratinocyte groth factor 2; FGFA; FGF-10 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE & silver stain
• Form/Format: Lyophilized
• Sequence: N-Terminal Sequence: MLGQDM
• Sequence Length: 208

• Buffer: 0.5X PBS

Testing Data

Testing Data #2

Related Product Information for FGF-10 active protein

Fibroblast Growth Factor-10 (FGF-10) is a heparin binding growth factor which stimulates the proliferation and activation of cells that express FGF receptors. FGF-10 is most related to KGF/FGF-7 and is expressed during development and preferentially in adult lungs. Human FGF-10 is a 19.3 kDa protein containing 170 amino acid residues.

Product Categories/Family for FGF-10 active protein

Cytokines & Growth Factors

References

1. Ohta H et al, Endocr Metab Immune Disord Drug Targets 2011;11(4):302-9 2. Krejci P et al, Hum Mutation 2009; 30(9):1245-55 3. Chung SS and Koh CJ; In Vitro Cell Dev Biol Anim 2013; 49(10):746-51 4. Volckaert T etal, Development 2013; 140(18):3731-42 5. Wells KL et al, Biol Open 2013; 2(10):981-9 6. Liu F et al, Development 2013; 140(5):1111-22 7. Volckaert T et al, PLoS One. 2013; 8(8):e71426 7. Gasperin BG et al, Reproduction 2012; 143(6):815-23 8. El Agha E et al, PLoS One. 2012; 7(6):e38452

NCBI and Uniprot Product Information

• NCBI GI #: 4758360
• NCBI GeneID: 2255
• NCBI Accession #: NP_004456.1
• NCBI GenBank Nucleotide #: NM_004465
• UniProt Accession #: O15520; Q6FHT6; Q96P59
• Molecular Weight: 19.3 kDa
• NCBI Official Full Name: fibroblast growth factor 10
• NCBI Official Synonym Full Names: fibroblast growth factor 10
• NCBI Official Symbol: FGF10
• NCBI Protein Information: fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria
• UniProt Protein Name: Fibroblast growth factor 10
• UniProt Gene Name: FGF10
• UniProt Synonym Gene Names: FGF-10
• UniProt Entry Name: FGF10_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Ref.8

Subunit structure: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Ref.7 Ref.8

Subcellular location: Secreted

Potential.

Involvement in disease: Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.13

Sequence similarities: Belongs to the heparin-binding growth factors family.