Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DUSP22 Polyclonal Antibody at dilution 1:60)
Rabbit DUSP22 Polyclonal Antibody | anti-DUSP22 antibody
DUSP22 Polyclonal Antibody
Gene Names
DUSP22; VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
DUSP22; Polyclonal Antibody; DUSP22 Polyclonal Antibody; VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2; anti-DUSP22 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
3mg/mL (varies by lot)
Sequence Length
205
Applicable Applications for anti-DUSP22 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:200
Immunogen
Recombinant protein of human DUSP22
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DUSP22 Polyclonal Antibody at dilution 1:60)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DUSP22 Polyclonal Antibody at dilution 1:60)
Related Product Information for anti-DUSP22 antibody
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
Product Categories/Family for anti-DUSP22 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
23,268 Da
NCBI Official Full Name
dual specificity protein phosphatase 22 isoform a
NCBI Official Synonym Full Names
dual specificity phosphatase 22
NCBI Official Symbol
DUSP22
NCBI Official Synonym Symbols
VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
NCBI Protein Information
dual specificity protein phosphatase 22; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP kinase phosphatase x; homolog of mouse dual specificity phosphatase LMW-DSP2; low molecular weight dual specificity phosphatase 2; mitogen-activated protein kinase phosphatase x
UniProt Protein Name
Dual specificity protein phosphatase 22
Protein Family
UniProt Gene Name
DUSP22
UniProt Synonym Gene Names
JSP1; LMWDSP2; MKPX; JSP-1; LMW-DSP2; MAP kinase phosphatase x; MKP-x
UniProt Entry Name
DUS22_HUMAN
Uniprot Description
DUSP22: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Apoptosis
Chromosomal Location of Human Ortholog: 6p25.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: cell proliferation; apoptosis; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; inactivation of MAPK activity; regulation of cell proliferation
Research Articles on DUSP22
Similar Products
Product Notes
The DUSP22 dusp22 (Catalog #AAA2520447) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DUSP22 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DUSP22 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the DUSP22 dusp22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DUSP22, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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