CD30 Ligand, soluble Active Protein | CD30 Ligand active protein

Human CD30 Ligand, soluble

Cat. Num. AAA691588

• Gene Names: TNFSF8; CD153; CD30L; CD30LG
• Reactivity: Human
• Purity: > 98% by SDS-PAGE gel and HPLC analyses.
• Synonyms: CD30 Ligand; soluble; Human CD30 Ligand; TNFSF8; CD153; CD30L; TNFSF8 tumor necrosis factor (ligand) superfamily; member 8; CD30 Ligand active protein

• Host: CHO Cells
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE gel and HPLC analyses.
• Form/Format: Lyophilized
• Sequence: HHHHHHHHPS PGGSGGQRTD SIPNSPDNVP LKGGNCSEDL LCILKR APFK KSWAYLQVAK HLNKTKLSWN KDGILHGVRY QDGNLVIQFP G LYFIICQLQ FLVQCPNNSV DLKLELLINK HIKKQALVTV CESGMQT KHV YQNLSQFLLD YLQVNTTISV NVDTFQYIDT STFPLENVLS IF LYSNSD
• Sequence Length: 234

• Label/Conjugation: His-Tag
• Biological Activity: Determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/ml. Note: Results may vary with PBMC donors.

Related Product Information for CD30 Ligand active protein

The type-II membrane-associated glycoprotein CD30 ligand (CD30L) is a protein belonging to the TNF superfamily. The CD30L gene encodes for a 234 amino acid type II transmembrane protein, which contains a 37 amino acid cytoplasmic sequence, a 25 amino acid transmembrane domain and a 172 amino acid extracellular domain. The protein is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds specifically to CD30 (receptor), which is expressed on activated, but not resting, B and T cells, in lymphomas and various chronically inflamed tissues. CD30L/CD30 interactions initiate a signaling cascade that can ultimately lead to the activation of NF-KappaB. CD30L/CD30 signaling exerts pleiotropic effects on normal cells, including cell death, differentiation, or cell division. Certain diseases, including Hodgkins's lymphoma, allergic inflammation, diabetes (in NOD mice), and mycobacterial infection can also be affected by CD30L/CD30 signaling. The provided recombinant human soluble CD30L (sCD30L) is a 188 amino acid polypeptide corresponding to the extracellular domain, and contains an 8 residue N-terminal His -Tag.

Product Categories/Family for CD30 Ligand active protein

Soluble receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4507607
• NCBI GeneID: 944
• NCBI Accession #: NP_001235.1
• NCBI GenBank Nucleotide #: NM_001244.3
• UniProt Accession #: P32971; O43404
• Molecular Weight: 26,017 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 8 isoform 1
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 8
• NCBI Official Symbol: TNFSF8
• NCBI Official Synonym Symbols: CD153; CD30L; CD30LG
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 8; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 8
• UniProt Gene Name: TNFSF8
• UniProt Synonym Gene Names: CD30L; CD30LG; CD30-L
• UniProt Entry Name: TNFL8_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

Function: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Subunit structure: Homotrimer

Probable.

Subcellular location: Membrane; Single-pass type II membrane protein.

Sequence similarities: Belongs to the tumor necrosis factor family.