K1199 Blocking Peptide | CEMIP blocking peptide
K1199 Antibody (C-term) Blocking peptide
Gene Names
CEMIP; CCSP1; HYBID; TMEM2L; KIAA1199
Synonyms
K1199; K1199 Antibody (C-term) Blocking peptide; Cell migration-inducing and hyaluronan-binding protein; CEMIP; KIAA1199; CEMIP blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1361
Cellular Location
Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted Note: Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP- dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues Localized in the nucleus and cytoplasm of colon adenocarcinomas
Tissue Location
Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for CEMIP blocking peptide
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
110,357 Da
NCBI Official Full Name
Cell migration-inducing and hyaluronan-binding protein
NCBI Official Synonym Full Names
cell migration inducing hyaluronan binding protein
NCBI Official Symbol
CEMIP
NCBI Official Synonym Symbols
CCSP1; HYBID; TMEM2L; KIAA1199
NCBI Protein Information
cell migration-inducing and hyaluronan-binding protein
UniProt Protein Name
Cell migration-inducing and hyaluronan-binding protein
Protein Family
UniProt Gene Name
CEMIP
UniProt Synonym Gene Names
KIAA1199
UniProt Entry Name
CEMIP_HUMAN
Uniprot Description
CEMIP: May be involved in hearing. Belongs to the TMEM2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.2.1.35
Chromosomal Location of Human Ortholog: 15q24
Cellular Component: clathrin coated vesicle membrane; cytoplasm; endoplasmic reticulum; extracellular region; plasma membrane
Molecular Function: clathrin heavy chain binding; ER retention sequence binding; hyaluronic acid binding; hyalurononglucosaminidase activity; protein binding
Biological Process: hyaluronan biosynthetic process; hyaluronan catabolic process; positive regulation of cell migration; positive regulation of release of sequestered calcium ion into cytosol; sensory perception of sound
Research Articles on CEMIP
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Product Notes
The CEMIP cemip (Catalog #AAA9218009) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "K1199, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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