Cysteine Dioxygenase Recombinant Protein | CDO1 recombinant protein

Recombinant Human Cysteine Dioxygenase

Cat. Num. AAA143627

• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Cysteine Dioxygenase; Recombinant Human Cysteine Dioxygenase; CDO1 Human; Cysteine Dioxygenase Human Recombinant; Cysteine dioxygenase type 1; Cysteine dioxygenase type I; CDO-I; CDO; CDO1; CDO1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: The CDO1 solution contains 20mM Tris buffer(pH 8.0), 10% glycerol and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMEQ TEVLKPRTLA DLIRILHQLF AGDEVNVEEV QAIMEAYESD PTEWAMYAKF DQYRYTRNLV DQGNGKFNLM ILCWGEGHGS SIHDHTNSHC FLKMLQGNLK ETLFAWPDKK SNEMVKKSER VLRENQCAYI NDSVGLHRVE NISHTEPAVS LHLYSPPFDT CHAFDQR
• Sequence Length: 200

• Preparation and Storage: CDO1 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Related Product Information for CDO1 recombinant protein

Description: CDO1 Human Recombinant fused with 37 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids (1-170 a.a.) and having a molecular mass of 23.9kDa.The CDO1 is purified by proprietary chromatographic techniques.

Introduction: CDO1 (Cysteine dioxygenase) is a mammalian non-heme iron enzyme that initiates a number of significant metabolic pathways associated with pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. CDO1 catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic concentration of intracellular free cysteine within a proper narrow range. CDO1 is able to alter intracellular cysteine levels and glutathione levels. CDO1 is highly expressed in the liver and placenta. On the other hand CDO1 has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells.

Product Categories/Family for CDO1 recombinant protein

Enzymes; Oxygenase

NCBI and Uniprot Product Information

• NCBI GI #: 56786147
• NCBI GeneID: 1036
• NCBI Accession #: NP_001792.2
• NCBI GenBank Nucleotide #: NM_001801.2
• UniProt Accession #: Q16878; P78513; Q6FHZ8; Q8TB64; B2RAK4
• Molecular Weight: 22,972 Da
• NCBI Official Full Name: cysteine dioxygenase type 1
• NCBI Official Synonym Full Names: cysteine dioxygenase type 1
• NCBI Official Symbol: CDO1
• NCBI Protein Information: cysteine dioxygenase type 1; CDO; CDO-I; cysteine dioxygenase, type I
• UniProt Protein Name: Cysteine dioxygenase type 1
• Protein Family: Cysteine dioxygenase
• UniProt Gene Name: CDO1
• UniProt Synonym Gene Names: CDO; CDO-I
• UniProt Entry Name: CDO1_HUMAN

Uniprot Description

CDO1: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. Belongs to the cysteine dioxygenase family.

Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; Oxidoreductase; EC 1.13.11.20; Amino Acid Metabolism - cysteine and methionine

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: cytosol

Molecular Function: cysteine dioxygenase activity; ferrous iron binding

Biological Process: lactation; cysteine metabolic process; sulfur amino acid biosynthetic process; response to ethanol; response to cAMP; response to glucagon stimulus; sulfur amino acid metabolic process; sulfur amino acid catabolic process; response to glucocorticoid stimulus; taurine biosynthetic process; inflammatory response; response to amino acid stimulus; L-cysteine catabolic process