SEC31A cdna clone

SEC31A cDNA Clone

Gene Names

SEC31A; ABP125; ABP130; HSPC275; HSPC334; SEC31L1

Synonyms

SEC31A; SEC31A cDNA Clone; SEC31A cdna clone

Ordering
Cat. Num. AAA1275352 For Research Use Only!

Sequence

atgaagttaaaggaagtagatcgtacagccatgcaggcatggagccctgcccagaatcaccccatttacctagcaacaggaacatctgctcagcaattggatgcaacatttagtacgaatgcttcccttgagatatttgaattagacctctctgatccatccttggatatgaaatcttgtgccacattctcctcttctcacaggtaccacaagttgatttgggggccttataaaatggattccaaaggagatgtctctggagttctgattgcaggtggtgaaaatggaaatattattctctatgatccttctaaaattatagctggagacaaggaagttgtgattgcccagaatgacaagcatactggcccagtgagagccttggatgtgaacattttccagactaatctggtagcttctggtgctaatgaatctgaaatctacatatgggatctaaataattttgcaaccccaatgacaccaggagccaaaacacagccgccagaagatatcagctgcattgcatggaacagacaagttcagcatattttagcatcagccagtcccagtggccgggccactgtatgggatcttaggaaaaatgagccaatcatcaaagtcagtgaccatagtaacagaatgcattgttctgggttggcatggcatcctgatgttgctactcagatggtccttgcctccgaggatgaccggttaccagtgatccagatgtgggatcttcgatttgcttcctctccacttcgtgtcctggaaaaccatgccagggggattttggcaattgcttggagcatggcagatcctgaattgttactgagctgtggaaaagatgctaagattctctgctccaatccaaacacaggagaggtgttatatgaacttcccaccaacacacagtggtgcttcgatattcagtggtgtccccgaaatcctgctgtcttatcagctgcttcgtttgatgggcgtatcagtgtttattctatcatgggaggaagcacagatggtttaagacagaaacaagttgacaagctttcatcatcttttgggaatcttgatccctttggcacaggacagccccttcctccgttacaaattccacagcagactgctcagcatagtatagtgctgcctctgaagaagccgcccaagtggattcgaaggcctgttggtgcttctttttcatttggaggcaaactggttacgtttgagaatgtcagaatgccttctcatcagggagctgagcagcagcagcagcagcaccatgtgttcattagtcaggttgtaacagaaaaggagttcctcagccgatcagaccaacttcagcaggctgtgcagtcacaaggatttatcaattattgccaaaaaaaaattgatgcttctcagactgaatttgagaaaaatgtgtggtcctttttgaaggtaaactttgaggatgattctcgtggaaaataccttgaacttctaggatacagaaaagaagatctaggaaagaagattgctttggccttgaacaaagtggatggagccaatgtggctcttaaagactctgaccaagtagcacagagtgatggggaggagagccctgctgctgaagagcagctcttgggagagcacattaaagaggaaaaagaagaatctgaatttctaccctcatctggaggaacatttaatatctctgtcagtggggacattgatggtttaattactcaggctttgctgacgggcaattttgagagtgctgttgacctttgtttacatgataaccgcatggccgatgccattatattggccatagcaggtggacaagaactcttggctcgaacccagaaaaaatacttcgcaaaatcccaaagcaaaattaccaggctcatcactgcagtggtgatgaagaactggaaagagattgttgagtcttgtgatcttaaaaattggagagaggctttagctgcagtattgacttatgcaaagccggatgaattttcagccctttgtgatcttttgggaaccaggcttgaaaatgaaggagatagcctcctgcagactcaagcatgtctctgctatatttgtgcagggaatgtagagaaattagttgcatgttggactaaagctcaagatggaagccaccctttgtcacttcaggatctgattgagaaagttgtcatcctgcgaaaagctgtgcaactcactcaagccatggacactagtactgtaggagttctcttggctgcgaagatgagtcagtatgccaatttgttggcagctcagggcagtattgctgcagccttggcttttcttcctgacaacaccaaccagccaaatatcatgcagcttcgtgacagactttgtagagcacaaggagagcctgtagcaggacatgaatcacctaaaattccgtacgagaaacagcagctccccaagggcaggcctggaccagttgctggccaccaccagatgccaagagttcaaactcaacaatattatccccatggagaaaatcctccacctccgggtttcataatgcatggaaatgttaatccaaatgctgctggtcagcttcccacatctccaggtcatatgcacacccaggtaccaccttatccacagccacagccttatcaaccagcccagccgtatcccttcggaacaggggggtcagcaatgtatcgacctcagcagcctgttgctcctcctacttcaaacgcttaccctaacaccccttacatatcttctgcttcttcctatactgggcagtctcagctgtacgcagcacagcaccaggcctcttcacctacctccagccctgctacttctttccctcctcccccttcctctggagcatccttccagcatggcggaccaggagctccaccatcatcttcagcttatgcactgcctcctggaacaacaggtcctcagaatggttggaatgaccctccagctttgaacagagtacccaaaaagaagaagatgcctgaaaacttcatgcctcctgttcccatcacatcaccaatcatgaacccgttgggtgacccccagtcacaaatgctgcagcaacagccttcagctccagtaccactgtcaagccagtcttcattcccacagccacatcttccaggtggccagcccttccatggcgtacagcaacctcttggtcaaacaggcatgccaccatctttttcaaagcccaatattgaaggtgccccaggggctcctattggaaataccttccagcatgtgcagtctttgccaacaaaaaaaattaccaagaaacctattccagatgagcacctcattctaaagaccacatttgaggatcttattcagcgctgcctttcttcagcaacagaccctcaaaccaagaggaagctagatgatgccagcaaacgtttggagtttctgtatgataaacttagggaacagacactttcaccaacaatcaccagtggtttacacaacattgcaaggagcattgaaactcgaaactactcagaaggattgaccatgcatacccacatagttagcaccagcaacttcagtgagacctctgctttcatgccagttctcaaagttgttctcacccaggccaataagctgggtgtctaa

Sequence Length

3618

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

109658675

NCBI GeneID

22872

Molecular Weight

127,556 Da

NCBI Official Full Name

Homo sapiens SEC31 homolog A (S. cerevisiae), mRNA

NCBI Official Synonym Full Names

SEC31 homolog A, COPII coat complex component

NCBI Official Symbol

SEC31A

NCBI Official Synonym Symbols

ABP125; ABP130; HSPC275; HSPC334; SEC31L1

NCBI Protein Information

protein transport protein Sec31A

UniProt Protein Name

Protein transport protein Sec31A

Protein Family

Protein transport protein

UniProt Gene Name

SEC31A

UniProt Synonym Gene Names

KIAA0905; SEC31L1

UniProt Entry Name

SC31A_HUMAN

NCBI Description

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

SEC31A: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. Abundantly and ubiquitously expressed. Belongs to the WD repeat SEC31 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Vesicle

Chromosomal Location of Human Ortholog: 4q21.22

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi transport vesicle; intracellular membrane-bound organelle; perinuclear region of cytoplasm

Molecular Function: calcium-dependent protein binding; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; response to calcium ion

Research Articles on SEC31A

1. Results show the crystal structure of the complex between ALG-2 and a peptide of Sec31A and found that the peptide binds to the third hydrophobic pocket (Pocket 3) and that ALG-2 recognizing 2 types of motifs at different hydrophobic surfaces of Sec31A.

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Product Notes

The SEC31A sec31a (Catalog #AAA1275352) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagttaa aggaagtaga tcgtacagcc atgcaggcat ggagccctgc ccagaatcac cccatttacc tagcaacagg aacatctgct cagcaattgg atgcaacatt tagtacgaat gcttcccttg agatatttga attagacctc tctgatccat ccttggatat gaaatcttgt gccacattct cctcttctca caggtaccac aagttgattt gggggcctta taaaatggat tccaaaggag atgtctctgg agttctgatt gcaggtggtg aaaatggaaa tattattctc tatgatcctt ctaaaattat agctggagac aaggaagttg tgattgccca gaatgacaag catactggcc cagtgagagc cttggatgtg aacattttcc agactaatct ggtagcttct ggtgctaatg aatctgaaat ctacatatgg gatctaaata attttgcaac cccaatgaca ccaggagcca aaacacagcc gccagaagat atcagctgca ttgcatggaa cagacaagtt cagcatattt tagcatcagc cagtcccagt ggccgggcca ctgtatggga tcttaggaaa aatgagccaa tcatcaaagt cagtgaccat agtaacagaa tgcattgttc tgggttggca tggcatcctg atgttgctac tcagatggtc cttgcctccg aggatgaccg gttaccagtg atccagatgt gggatcttcg atttgcttcc tctccacttc gtgtcctgga aaaccatgcc agggggattt tggcaattgc ttggagcatg gcagatcctg aattgttact gagctgtgga aaagatgcta agattctctg ctccaatcca aacacaggag aggtgttata tgaacttccc accaacacac agtggtgctt cgatattcag tggtgtcccc gaaatcctgc tgtcttatca gctgcttcgt ttgatgggcg tatcagtgtt tattctatca tgggaggaag cacagatggt ttaagacaga aacaagttga caagctttca tcatcttttg ggaatcttga tccctttggc acaggacagc cccttcctcc gttacaaatt ccacagcaga ctgctcagca tagtatagtg ctgcctctga agaagccgcc caagtggatt cgaaggcctg ttggtgcttc tttttcattt ggaggcaaac tggttacgtt tgagaatgtc agaatgcctt ctcatcaggg agctgagcag cagcagcagc agcaccatgt gttcattagt caggttgtaa cagaaaagga gttcctcagc cgatcagacc aacttcagca ggctgtgcag tcacaaggat ttatcaatta ttgccaaaaa aaaattgatg cttctcagac tgaatttgag aaaaatgtgt ggtccttttt gaaggtaaac tttgaggatg attctcgtgg aaaatacctt gaacttctag gatacagaaa agaagatcta ggaaagaaga ttgctttggc cttgaacaaa gtggatggag ccaatgtggc tcttaaagac tctgaccaag tagcacagag tgatggggag gagagccctg ctgctgaaga gcagctcttg ggagagcaca ttaaagagga aaaagaagaa tctgaatttc taccctcatc tggaggaaca tttaatatct ctgtcagtgg ggacattgat ggtttaatta ctcaggcttt gctgacgggc aattttgaga gtgctgttga cctttgttta catgataacc gcatggccga tgccattata ttggccatag caggtggaca agaactcttg gctcgaaccc agaaaaaata cttcgcaaaa tcccaaagca aaattaccag gctcatcact gcagtggtga tgaagaactg gaaagagatt gttgagtctt gtgatcttaa aaattggaga gaggctttag ctgcagtatt gacttatgca aagccggatg aattttcagc cctttgtgat cttttgggaa ccaggcttga aaatgaagga gatagcctcc tgcagactca agcatgtctc tgctatattt gtgcagggaa tgtagagaaa ttagttgcat gttggactaa agctcaagat ggaagccacc ctttgtcact tcaggatctg attgagaaag ttgtcatcct gcgaaaagct gtgcaactca ctcaagccat ggacactagt actgtaggag ttctcttggc tgcgaagatg agtcagtatg ccaatttgtt ggcagctcag ggcagtattg ctgcagcctt ggcttttctt cctgacaaca ccaaccagcc aaatatcatg cagcttcgtg acagactttg tagagcacaa ggagagcctg tagcaggaca tgaatcacct aaaattccgt acgagaaaca gcagctcccc aagggcaggc ctggaccagt tgctggccac caccagatgc caagagttca aactcaacaa tattatcccc atggagaaaa tcctccacct ccgggtttca taatgcatgg aaatgttaat ccaaatgctg ctggtcagct tcccacatct ccaggtcata tgcacaccca ggtaccacct tatccacagc cacagcctta tcaaccagcc cagccgtatc ccttcggaac aggggggtca gcaatgtatc gacctcagca gcctgttgct cctcctactt caaacgctta ccctaacacc ccttacatat cttctgcttc ttcctatact gggcagtctc agctgtacgc agcacagcac caggcctctt cacctacctc cagccctgct acttctttcc ctcctccccc ttcctctgga gcatccttcc agcatggcgg accaggagct ccaccatcat cttcagctta tgcactgcct cctggaacaa caggtcctca gaatggttgg aatgaccctc cagctttgaa cagagtaccc aaaaagaaga agatgcctga aaacttcatg cctcctgttc ccatcacatc accaatcatg aacccgttgg gtgaccccca gtcacaaatg ctgcagcaac agccttcagc tccagtacca ctgtcaagcc agtcttcatt cccacagcca catcttccag gtggccagcc cttccatggc gtacagcaac ctcttggtca aacaggcatg ccaccatctt tttcaaagcc caatattgaa ggtgccccag gggctcctat tggaaatacc ttccagcatg tgcagtcttt gccaacaaaa aaaattacca agaaacctat tccagatgag cacctcattc taaagaccac atttgaggat cttattcagc gctgcctttc ttcagcaaca gaccctcaaa ccaagaggaa gctagatgat gccagcaaac gtttggagtt tctgtatgat aaacttaggg aacagacact ttcaccaaca atcaccagtg gtttacacaa cattgcaagg agcattgaaa ctcgaaacta ctcagaagga ttgaccatgc atacccacat agttagcacc agcaacttca gtgagacctc tgctttcatg ccagttctca aagttgttct cacccaggcc aataagctgg gtgtctaa. It is sometimes possible for the material contained within the vial of "SEC31A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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SEC31A cdna clone