LIN7A cdna clone

LIN7A cDNA Clone

Cat. Num. AAA1274561

• Gene Names: LIN7A; LIN7; VELI1; LIN-7A; MALS-1; TIP-33
• Synonyms: LIN7A; LIN7A cDNA Clone; LIN7A cdna clone

• Sequence: ATGCTGAAGCCGAGCGTCACTTCGGCTCCCACGGCAGACATGGCGACATTGACAGTGGTCCAGCCGCTCACCCTGGACAGAGATGTTGCAAGAGCAATTGAATTACTGGAAAAACTACAGGAATCTGGAGAAGTACCAGTGCACAAGCTACAATCCCTCAAAAAAGTGCTTCAGAGTGAGTTTTGTACAGCTATTCGAGAGGTGTATCAATATATGCATGAAACGATAACTGTTAATGGCTGTCCCGAATTCCGTGCGAGGGCAACAGCAAAGGCAACAGTTGCAGCTTTTGCAGCTAGTGAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGCCTTGGTTTTAATGTGATGGGAGGAAAGGAGCAAAATTCCCCCATTTATATCTCTCGCATAATTCCTGGAGGGGTGGCTGAAAGACACGGAGGCCTCAAAAGAGGAGACCAGCTGCTATCAGTGAACGGAGTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCTGCTAAAGACAGCGTCAAGCTGGTGGTGCGATACACCCCAAAAGTTCTGGAAGAAATGGAGGCTCGCTTTGAAAAGCTACGAACAGCCAGGCGTCGGCAGCAGCAGCAATTGCTAATTCAGCAGCAGCAACAGCAGCAGCAGCAACAAACACAACAAAACCACATGTCATAG
• Sequence Length: 702

• Vector: pENTR223.1 or pUC
• Clone Sequence Report: Provided with product shipment

NCBI and Uniprot Product Information

• NCBI GI #: 110002632
• NCBI GeneID: 8825
• Molecular Weight: 25,997 Da
• NCBI Official Full Name: Homo sapiens lin-7 homolog A (C. elegans), mRNA
• NCBI Official Synonym Full Names: lin-7 homolog A, crumbs cell polarity complex component
• NCBI Official Symbol: LIN7A
• NCBI Official Synonym Symbols: LIN7; VELI1; LIN-7A; MALS-1; TIP-33
• NCBI Protein Information: protein lin-7 homolog A
• UniProt Protein Name: Protein lin-7 homolog A
• Protein Family: Protein
• UniProt Gene Name: LIN7A
• UniProt Synonym Gene Names: MALS1; VELI1; Lin-7A; hLin-7; MALS-1; TIP-33; Veli-1
• UniProt Entry Name: LIN7A_HUMAN

NCBI Description

The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]

Uniprot Description

LIN7A: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Adaptor/scaffold; Cell adhesion

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: basolateral plasma membrane; intercellular junction; plasma membrane

Molecular Function: protein binding

Biological Process: maintenance of epithelial cell polarity; neurotransmitter secretion; protein complex assembly