Rabbit anti-Human LIN7A Polyclonal Antibody | anti-LIN7A antibody

LIN7A Antibody

Cat. Num. AAA7001575

• Gene Names: LIN7A; LIN7; VELI1; LIN-7A; MALS-1; TIP-33
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >95%,Protein G purified
• Synonyms: LIN7A; Polyclonal Antibody; LIN7A Antibody; Protein lin-7 homolog A; Lin-7A; hLin-7; Mammalian lin-seven protein 1; MALS-1; Tax interaction protein 33; TIP-33; Vertebrate lin-7 homolog 1; Veli-1; MALS1; VELI1; anti-LIN7A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 233

• Applicable Applications for anti-LIN7A antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Recombinant human Protein lin-7 homolog A protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11496 / sc-11499
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Western Blot (WB)

(Western blotAll lanes: Lin7a antibody at 6ug/mlLane 1: Human placenta tissueLane 2: Mouse kidney tissueLane 3: Mouse liver tissueLane 4: Zebrafish lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 26 kDaObserved band size: 26,35,43,160 kDa)

Related Product Information for anti-LIN7A antibody

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

NCBI and Uniprot Product Information

• NCBI GI #: 4759306
• NCBI GeneID: 8825
• NCBI Accession #: NP_004655.1
• NCBI GenBank Nucleotide #: NM_004664.2
• UniProt Accession #: O14910; Q147W1; Q6LES3; Q7LDS4; A4FTY3
• Molecular Weight: 25,997 Da
• NCBI Official Full Name: protein lin-7 homolog A
• NCBI Official Synonym Full Names: lin-7 homolog A, crumbs cell polarity complex component
• NCBI Official Symbol: LIN7A
• NCBI Official Synonym Symbols: LIN7; VELI1; LIN-7A; MALS-1; TIP-33
• NCBI Protein Information: protein lin-7 homolog A
• UniProt Protein Name: Protein lin-7 homolog A
• Protein Family: Protein
• UniProt Gene Name: LIN7A
• UniProt Synonym Gene Names: MALS1; VELI1; Lin-7A; hLin-7; MALS-1; TIP-33; Veli-1
• UniProt Entry Name: LIN7A_HUMAN

Uniprot Description

LIN7A: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Cell adhesion; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: basolateral plasma membrane; intercellular junction; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; tight junction

Molecular Function: protein binding

Biological Process: exocytosis; inner ear development; maintenance of epithelial cell polarity; neurotransmitter secretion; protein complex assembly; protein transport; synaptic transmission; synaptic vesicle transport