LEFTY2 cdna clone
LEFTY2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Uniprot Description
LEFTY2: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Defects in LEFTY2 are the cause of left-right axis malformations (LRAM). The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Belongs to the TGF-beta family.
Protein type: Cytokine; Ligand, receptor tyrosine kinase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q42.1
Cellular Component: extracellular matrix; extracellular region; extracellular space
Molecular Function: cytokine activity; transforming growth factor beta receptor binding
Biological Process: cell development; platelet degranulation; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway
Research Articles on LEFTY2
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Product Notes
The LEFTY2 lefty2 (Catalog #AAA1276801) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtggcccc tgtggctctg ctgggcactc tgggtgctgc ccctggctgg ccccggggcg gccctgaccg aggagcagct cctgggcagc ctgctgcggc agctgcagct cagcgaggtg cccgtactgg acagggccga catggagaag ctggtcatcc ccgcccacgt gagggcccag tatgtagtcc tgctgcggcg cagccacggg gaccgctccc gcggaaagag gttcagccag agcttccgag aggtggccgg caggttcctg gcgtcggagg ccagcacaca cctgctggtg ttcggcatgg agcagcggct gccgcccaac agcgagctgg tgcaggccgt gctgcggctc ttccaggagc cggtccccaa ggccgcgctg cacaggcacg ggcggctgtc cccgcgcagc gcccaggccc gggtgaccgt cgagtggctg cgcgtccgcg acgacggctc caaccgcacc tccctcatcg actccaggct ggtgtccgtc cacgagagcg gctggaaggc cttcgacgtg accgaggccg tgaacttctg gcagcagctg agccggcccc ggcagccgct gctgctacag gtgtcggtgc agagggagca tctgggcccg ctggcgtccg gcgcccacaa gctggtccgc tttgcctcgc agggggcgcc agccgggctt ggggagcccc agctggagct gcacaccctg gacctcaggg actatggagc tcagggcgac tgtgaccctg aagcaccaat gaccgagggc acccgctgct gccgccagga gatgtacatt gacctgcagg ggatgaagtg ggccaagaac tgggtgctgg agcccccggg cttcctggct tacgagtgtg tgggcacctg ccagcagccc ccggaggccc tggccttcaa ttggccattt ctggggccgc gacagtgtat cgcctcggag actgcctcgc tgcccatgat cgtcagcatc aaggagggag gcaggaccag gccccaggtg gtcagcctgc ccaacatgag ggtgcagaag tgcagctgtg cctcggatgg ggcgctcgtg ccaaggaggc tccagccata g. It is sometimes possible for the material contained within the vial of "LEFTY2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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