Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 2ug/ml Rabbit Anti-Human LBP Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Human Lipopolysaccharide Binding Protein (LBP) Polyclonal Antibody | anti-LBP antibody
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP)
MGHHHHHHSGSEF-NPGLVARITD KGLQYAAQEG LLALQSELLR ITLPDFTGDL RIPHVGRGRY EFHSLNIHSC ELLHSALRPV PGQGLSLSIS DSSIRVQGRW KVRKSFFKLQ GSFDVSVKGI SISVNLLLGS ESSGRPTVTA SSCSSDIADV EVDMSGDLGW LLNLFHNQIE SKFQKVLESR ICEMIQKSVS SDLQPYLQTL PVTTEIDSFA DIDYSLVEAP RATAQMLEVM FKGEIFHRNH RSPVTLLAAV MSLPEEHNKM VYFAISDYVF NTASLVYHEE GYLNFSITDD MIPPDSNIRL TTKSFRPFVP RLARLYPNMN LELQGSVPSA PLLNFSPGNL SVDPYMEIDA FVLLPSSSKE PVFRLSVATN VSATLTFNTS KITGFLKPGK VKVELKESKV GLFNAELLEA LLNYYILNTF YPKFNDKLAE GFPLPLLKRV QLYDLGLQIH KDFLFLGANV QYMRV
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 2ug/ml Rabbit Anti-Human LBP Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 2ug/ml Rabbit Anti-Human LBP Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Uniprot Description
LBP: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component: cell surface; extracellular region; extracellular space; membrane
Molecular Function: lipopolysaccharide binding; protein binding; receptor binding
Biological Process: acute-phase response; cellular defense response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of molecule of bacterial origin; innate immune response; leukocyte chemotaxis involved in inflammatory response; lipopolysaccharide transport; lipopolysaccharide-mediated signaling pathway; macromolecule localization; macrophage activation involved in immune response; negative regulation of tumor necrosis factor production; opsonization; positive regulation of chemokine production; positive regulation of cytolysis; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of macrophage activation; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; response to lipopolysaccharide; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway
Research Articles on LBP
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Product Notes
The LBP lbp (Catalog #AAA2002217) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lipopolysaccharide Binding Protein (LBP) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the LBP lbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-NPGLVA RITD KGLQYAAQEG LLALQSELLR ITLPDFTGDL RIPHVGRGRY EFHSLNIHSC ELLHSALRPV PGQGLSLSIS DSSIRVQGRW KVRKSFFKLQ GSFDVSVKGI SISVNLLLGS ESSGRPTVTA SSCSSDIADV EVDMSGDLGW LLNLFHNQIE SKFQKVLESR ICEMIQKSVS SDLQPYLQTL PVTTEIDSFA DIDYSLVEAP RATAQMLEVM FKGEIFHRNH RSPVTLLAAV MSLPEEHNKM VYFAISDYVF NTASLVYHEE GYLNFSITDD MIPPDSNIRL TTKSFRPFVP RLARLYPNMN LELQGSVPSA PLLNFSPGNL SVDPYMEIDA FVLLPSSSKE PVFRLSVATN VSATLTFNTS KITGFLKPGK VKVELKESKV GLFNAELLEA LLNYYILNTF YPKFNDKLAE GFPLPLLKRV QLYDLGLQIH KDFLFLGANV QYMRV. It is sometimes possible for the material contained within the vial of "Lipopolysaccharide Binding Protein (LBP), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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