GABARAPL2 cdna clone
GABARAPL2 cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
GABARAPL2: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Implicated in intra-Golgi transport and post-mitotic Golgi re-assembly. Modulates the activity of SNAREs in the Golgi apparatus and is therefore an essential component of intra-Golgi transport and post-mitotic Golgi re-assembly. It first stimulates the ATPase activity of NSF, which in turn stimulates the association with GOSR1. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin. Interacts with ULK1. Phosphorylated upon DNA damage, probably by ATM or ATR.
Protein type: Autophagy; Adaptor/scaffold; Ubiquitin-like modifier; Vesicle; Microtubule-binding
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: Golgi membrane; Golgi apparatus; extrinsic to membrane; cytoplasm; autophagic vacuole; cytoplasmic vesicle; intracellular; cytosol
Molecular Function: protein binding; SNARE binding; microtubule binding; beta-tubulin binding; GABA receptor binding; ATPase binding
Biological Process: intra-Golgi vesicle-mediated transport; protein transport; positive regulation of ATPase activity; mitochondrion degradation; autophagy; cellular response to nitrogen starvation; autophagic vacuole formation
Research Articles on GABARAPL2
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Product Notes
The GABARAPL2 gabarapl2 (Catalog #AAA1277093) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagtgga tgttcaagga ggaccactcg ctggaacaca gatgcgtgga gtccgcgaag attcgagcga aatatcccga cagggttccg gtgattgtgg aaaaggtctc aggctctcag attgttgaca ttgacaaacg gaagtacttg gtcccatctg atatcactgt ggctcagttc atgtggatca tcaggaaaag gatccagctt ccttctgaaa aggcgatctt cctgtttgtg gataagacag tcccacagtc cagcctaact atgggacagc tttacgagaa ggaaaaagat gaagatggat tcttatatgt ggcctacagc ggagagaaca cttttggctt ctga. It is sometimes possible for the material contained within the vial of "GABARAPL2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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