EFCAB4B cdna clone

EFCAB4B cDNA Clone

Cat. Num. AAA1271966

• Gene Names: CRACR2A; EFCAB4B
• Synonyms: EFCAB4B; EFCAB4B cDNA Clone; EFCAB4B cdna clone

• Sequence: atggctgcccctgacgggagggtagtctccagaccccagagacttggtcaggggtctggccaggggccaaaggggagtggagcctgcctgcatcccctggacagcctggagcagaaggagactcaggagcaaacgtcgggccagctagtcatgctgaggaaggcacaggagttctttcagacctgtgatgctgaaggcaagggcttcatcgccaggaaggatatgcagaggctgcataaggagctaccgctcagcctggaggaactggaggatgtgtttgatgccctggatgctgatggcaatggctatctgaccccacaggagttcactactggatttagtcacttcttcttcagccagaataacccaagtcaggaagatgcaggtgaacaggtggcccagcgccatgaagagaaggtgtatctgtccagaggggatgaggatctgggcgacatgggcgaagatgaggaagcccagttccggatgctgatggacagacttggagcccaaaaggtgttggaagatgaaagtgatgtcaagcagctctggttgcagctgaagaaggaggaacctcatttactgtccaactttgaagacttcctgaccagaatcatctcccagctccaagaagcccatgaggagaagaatgaactggagtgtgccctaaaaaggaaaattgctgcttatgatgaagaaatccagcatctctatgaggagatggaacaacaaatcaaaagtgagaaggagcagtttctcctgaaggacacagagaggtttcaagcccgcagtcaagagctggagcagaaactgttatgtaaggagcaggagctggagcagctcacccagaagcagaaaaggctggaaggtcagtgcacagccctgcatcatgacaagcatgagaccaaggctgagaataccaagctgaaactcactaaccaggagctggcccgggagctggagcggacttcctgggagctccaggatgctcagcagcagttggaaagcctccagcaagaggcctgcaaactccaccaagagaaggagatggaagtgtaccgtgtgacggagagtctacagcgtgagaaggccgggctcctcaagcagctggatttcctaaggtgcgtcggtgggcactggcctgtgctgagagcacctcccagaagcctggggtcggaaggaccagtctga
• Sequence Length: 1188

• Vector: pENTR223.1 or pUC
• Clone Sequence Report: Provided with product shipment

NCBI and Uniprot Product Information

• NCBI GI #: 33990978
• NCBI GeneID: 84766
• Molecular Weight: 83,193 Da
• NCBI Official Full Name: Homo sapiens EF-hand calcium binding domain 4B, mRNA
• NCBI Official Synonym Full Names: calcium release activated channel regulator 2A
• NCBI Official Symbol: CRACR2A
• NCBI Official Synonym Symbols: EFCAB4B
• NCBI Protein Information: EF-hand calcium-binding domain-containing protein 4B
• UniProt Protein Name: EF-hand calcium-binding domain-containing protein 4B
• UniProt Gene Name: CRACR2A
• UniProt Synonym Gene Names: EFCAB4B; CRAC channel regulator 2A
• UniProt Entry Name: EFC4B_HUMAN

Uniprot Description

EFCAB4B: Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Belongs to the EFCAB4 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 12p13.32

Cellular Component: cytoplasm; Golgi apparatus; membrane; nucleolus; nucleus

Molecular Function: calcium ion binding; protein binding

Biological Process: activation of store-operated calcium channel activity; positive regulation of calcium ion transport