CLPB cdna clone
CLPB cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
CLPB: May function as a regulatory ATPase and be related to secretion/protein trafficking process. Belongs to the clpA/clpB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 11q13.4
Molecular Function: protein binding
Disease: 3-methylglutaconic Aciduria With Cataracts, Neurologic Involvement, And Neutropenia
Research Articles on CLPB
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Product Notes
The CLPB clpb (Catalog #AAA1272447) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgctaaaaa gttggtactt gcttgtttcc acacagggct tcatcaggct ggacatgtcc gagttccagg agcgacacga ggtggccaag tttattgggt ctccaccagg ctacgttggc catgaggagg gtggccagct gaccaagaag ttgaagcagt gccccaatgc tgtggtgctc tttgatgaag tagacaaggc ccatccagat gtgctcacca tcatgctgca gctgtttgat gagggccggc tgacagatgg aaaagggaag accattgatt gcaaggacgc catcttcatc atgacctcca atgtggccag cgacgagatc gcacagcacg cgctgcagct gaggcaggaa gctttggaga tgagccgtaa ccgtattgcc gaaaacctgg gggatgtcca gataagtgac aagatcacca tctcaaagaa cttcaaggag aatgtgattc gccctatcct gaaagctcac ttccggaggg atgagtttct gggacggatc aatgagatcg tctacttcct ccccttctgc cactcggagc tcatccaact cgtcaacaag gaactaaact tctgggccaa gagagccaag caaaggcaca acatcacgct gctctgggac cgcgaggtgg cagatgtgct ggtcgacggc tacaatgtgc actatggcgc ccgctccatc aaacatgagg tagaacgccg tgtggtgaac cagctggcag cagcctatga gcaggacctg ctgccagggg gctgtacttt gcgcatcacg gtggaggact cagacaagca gctactcaaa agcccagaac tgccctcacc ccaggctgag aagcgcctcc ccaagctgcg tctggagatc atcgacaagg acagcaagac tcgcagactg gacatccggg caccactgca ccctgagaag gtgtgcaaca ccatctag. It is sometimes possible for the material contained within the vial of "CLPB, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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