Cadherin-6 Protein Recombinant Protein | CDH6 recombinant protein

Recombinant Human Cadherin-6 Protein

Cat. Num. AAA2556737

• Gene Names: CDH6; CAD6; KCAD
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Cadherin-6 Protein; Recombinant Human Cadherin-6 Protein; Cadherin-6; Kidney Cadherin; K-Cadherin; CDH6; CDH6 recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Length: 663

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Thr22-Ala615
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for CDH6 recombinant protein

Protein Construction: Recombinant Human Cadherin-6 is produced by our Mammalian expression system and the target gene encoding Thr22-Ala615 is expressed with a 6His tag at the C-terminus.

Background: Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14.

NCBI and Uniprot Product Information

• NCBI GI #: 12652559
• NCBI GeneID: 1004
• Molecular Weight: Molecular Mass: 67.4kDa; Actual Protein Molecular Mass: 109kDa
• NCBI Official Full Name: CDH6 protein
• NCBI Official Synonym Full Names: cadherin 6
• NCBI Official Symbol: CDH6
• NCBI Official Synonym Symbols: CAD6; KCAD
• NCBI Protein Information: cadherin-6
• UniProt Protein Name: Cadherin-6
• Protein Family: Cadherin
• UniProt Gene Name: CDH6
• UniProt Synonym Gene Names: K-cadherin

NCBI Description

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

Uniprot Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.