Cadherin-3 Recombinant Protein | Cdh3 recombinant protein

Cadherin-3

Cat. Num. AAA7042537

• Gene Names: Cdh3; Cadp; Cdhp; Pcad; AI385538; P-cadherin
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cadherin-3; Cdh3 recombinant protein

• Host: Cell Free Expression
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 100-822aa; full length protein
• Sequence: EWVMPPIFVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVLEGVMPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISSGLDREKVPEYRLTVQATDMDGEGSTTTAEAVVQILDANDNAPEFEPQKYEAWVPENEVGHEVQRLTVTDLDVPNSPAWRATYHIVGGDDGDHFTITTHPETNQGVLTTKKGLDFEAQDQHTLYVEVTNEAPFAVKLPTATATVVVHVKDVNEAPVFVPPSKVIEAQEGISIGELVCIYTAQDPDKEDQKISYTISRDPANWLAVDPDSGQITAAGILDREDEQFVKNNVYEVMVLATDSGNPPTTGTGTLLLTLTDINDHGPIPEPRQIIICNQSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWMAEVSEKGDTVALSLKKFLKQDTYDLHLSLSDHGNREQLTMIRATVCDCHGQVFNDCPRPWKGGFILPILGAVLALLTLLLALLLLVRKKRKVKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVVPTFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTTSASDQDQDYNYLNEWGSRFKKLADMYGGGEDD
• Sequence Length: Full Length Protein

• Species: Mus musculus (Mouse)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.; Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for Cdh3 recombinant protein

This is a recombinant transmembrane protein expressed in a cell-free expression system.

Product Categories/Family for Cdh3 recombinant protein

Transmembrane Protein

NCBI and Uniprot Product Information

• NCBI GI #: 83715978
• NCBI GeneID: 12560
• NCBI Accession #: NP_001032898.1
• NCBI GenBank Nucleotide #: NM_001037809.5
• UniProt Accession #: P10287; Q61465; Q8BSL6
• Molecular Weight: 90,612 Da
• NCBI Official Full Name: cadherin-3 isoform a preproprotein
• NCBI Official Synonym Full Names: cadherin 3
• NCBI Official Symbol: Cdh3
• NCBI Official Synonym Symbols: Cadp; Cdhp; Pcad; AI385538; P-cadherin
• NCBI Protein Information: cadherin-3
• UniProt Protein Name: Cadherin-3
• Protein Family: Cadherin
• UniProt Gene Name: Cdh3
• UniProt Synonym Gene Names: Cdhp; P-cadherin
• UniProt Entry Name: CADH3_MOUSE

NCBI Description

This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Uniprot Description

CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Cellular Component: cell-cell adherens junction; cytoplasm; plasma membrane

Biological Process: cell-cell adhesion; hair cycle process; keratinization; negative regulation of catagen; negative regulation of transforming growth factor-beta2 production; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of melanin biosynthetic process; positive regulation of monophenol monooxygenase activity; retinal homeostasis; Wnt receptor signaling pathway through beta-catenin