Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Cadherin Polyclonal Antibody | anti-CDHP antibody
Polyclonal Antibody to Cadherin, Placental (CDHP)
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-SPNSSP FQAQLTHDSD IYWMAEVSEK GDTVALSLKK FLKQDTYDLH LSLSDHGNRE QLTMIRATVC DCHGQVFNDC PRPWKGGFIL PILGAVLALL TLLLALLLLV RKKRKVKEPL LLPEDDTRDN VFYYGEEGGG EEDQDYDITQ LHRGLEARPE VVLRNDVVPT FIPTPMYRPR PANPDEIGNF IIENLKAANT DPTAPPYDSL LVFDYEGSGS DAASLSSLTT SASDQDQDYN YLNEWGSRFK KLADMYGGGE DD
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Description
CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8 D3|8 53.16 cM
Cellular Component: cell-cell adherens junction; cytoplasm; integral component of membrane; membrane; plasma membrane
Molecular Function: calcium ion binding; metal ion binding
Biological Process: cell adhesion; hair cycle process; homophilic cell adhesion; keratinization; negative regulation of catagen; negative regulation of transforming growth factor-beta2 production; positive regulation of gene expression; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of keratinocyte proliferation; positive regulation of melanin biosynthetic process; positive regulation of monophenol monooxygenase activity; retinal homeostasis; Wnt receptor signaling pathway through beta-catenin
Research Articles on CDHP
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Product Notes
The CDHP cdh3 (Catalog #AAA2028155) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Cadherin, Placental (CDHP) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cadherin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the CDHP cdh3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and GST-tag and its sequence is listed below. MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -SPNSSP FQAQLTHDSD IYWMAEVSEK GDTVALSLKK FLKQDTYDLH LSLSDHGNRE QLTMIRATVC DCHGQVFNDC PRPWKGGFIL PILGAVLALL TLLLALLLLV RKKRKVKEPL LLPEDDTRDN VFYYGEEGGG EEDQDYDITQ LHRGLEARPE VVLRNDVVPT FIPTPMYRPR PANPDEIGNF IIENLKAANT DPTAPPYDSL LVFDYEGSGS DAASLSSLTT SASDQDQDYN YLNEWGSRFK KLADMYGGGE DD. It is sometimes possible for the material contained within the vial of "Cadherin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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