CD89 / FCAR recombinant protein
Recombinant Rat CD89 / FCAR Protein (His tag)
Gene Names
Fcar; CD89
Purity
> 95 % as determined by SDS-PAGE
Synonyms
CD89 / FCAR; Recombinant Rat CD89 / FCAR Protein (His tag); CD89; CD89 / FCAR recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
280
Application Notes
The recombinant rat FCAR comprises 217 amino acids and predicts a molecular mass of 24.8 kDa. The apparent molecular mass of the rat FCAR is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Glu 23
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for CD89 / FCAR recombinant protein
Background: FCAR, also called FcalphaRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcalphaRI associates with the FcR gamma signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcalphaRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcalphaRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
Description: A DNA sequence encoding the rat FCAR (NP_973721.1) extracellular domain (Met 1-Asn 228) was expressed, fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat FCAR (NP_973721.1) extracellular domain (Met 1-Asn 228) was expressed, fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
immunoglobulin alpha Fc receptor
NCBI Official Synonym Full Names
Fc fragment of IgA receptor
NCBI Official Symbol
Fcar
NCBI Official Synonym Symbols
CD89
NCBI Protein Information
immunoglobulin alpha Fc receptor
Research Articles on CD89 / FCAR
Similar Products
Product Notes
The CD89 / FCAR (Catalog #AAA2547505) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat FCAR comprises 217 amino acids and predicts a molecular mass of 24.8 kDa. The apparent molecular mass of the rat FCAR is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the CD89 / FCAR for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD89 / FCAR, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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