CD81 recombinant protein

Recombinant Human CD81 (N-FC)

Cat. Num. AAA2569192

• Gene Names: CD81; S5.7; CVID6; TAPA1; TSPAN28
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: CD81; Recombinant Human CD81 (N-FC); CD81 antigen; CD81 molecule; CVID6; TAPA1; TAPA-1; TSPAN28; CD81 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Phe113-Lys201

• Species: Human
• Tag: N-Fc
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human CD81 antigen is produced by our Mammalian expression system and the target gene encoding Phe113-Lys201 is expressed with a Fc tag at the N-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for CD81 recombinant protein

CD81, also known as TAPA-1 and Tetraspanin-28, belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Members of this family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. CD81 associates with a wide range of membrane proteins including CD151, TfR2, LDL R, PCSK9, Glypican 3, IFITM1, IGSF8/CD316, FPRP, and complexes of CD19-CD21. It is related to adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. CD81 additionally functions as a receptor for the E2 glycoprotein of hepatitis C virus. The CD81-E2 interaction inhibits NK cell cytolytic activity, provides a co-stimulatory signal to T cells, and inhibits the maturation of plasmacytoid dendritic cells.

Product Categories/Family for CD81 recombinant protein

Microbiology; immunology

NCBI and Uniprot Product Information

• NCBI GI #: 38503376
• NCBI GeneID: 975
• UniProt Accession #: P60033; P18582; Q5U0J6
• Molecular Weight: 25,809 Da
• NCBI Official Full Name: CD81 antigen
• NCBI Official Synonym Full Names: CD81 molecule
• NCBI Official Symbol: CD81
• NCBI Official Synonym Symbols: S5.7; CVID6; TAPA1; TSPAN28
• NCBI Protein Information: CD81 antigen
• UniProt Protein Name: CD81 antigen
• Protein Family: CD81 antigen
• UniProt Gene Name: CD81
• UniProt Synonym Gene Names: TAPA1; TSPAN28; Tspan-28

NCBI Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Description

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.