H-2 class II histocompatibility antigen gamma chain Recombinant Protein | HG2A recombinant protein

Recombinant mouse H-2 class II histocompatibility antigen gamma chain

Cat. Num. AAA9420094

• Gene Names: Cd74; Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
• Reactivity: Mouse
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: H-2 class II histocompatibility antigen gamma chain; Recombinant mouse H-2 class II histocompatibility antigen gamma chain; Ia antigen-associated invariant chain; IiMHC class II-associated invariant chain; CD74; HG2A recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Extracellular Domain, 56-279aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for HG2A recombinant protein

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

NCBI and Uniprot Product Information

• NCBI GI #: 110624770
• NCBI GeneID: 16149
• NCBI Accession #: NP_001036070.1
• NCBI GenBank Nucleotide #: NM_001042605.1
• UniProt Accession #: P04441; O19452
• Molecular Weight: 29.5kD
• NCBI Official Full Name: H-2 class II histocompatibility antigen gamma chain isoform 1
• NCBI Official Synonym Full Names: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
• NCBI Official Symbol: Cd74
• NCBI Official Synonym Symbols: Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
• NCBI Protein Information: H-2 class II histocompatibility antigen gamma chain
• UniProt Protein Name: H-2 class II histocompatibility antigen gamma chain
• Protein Family: H-2 class II histocompatibility antigen
• UniProt Gene Name: Cd74
• UniProt Synonym Gene Names: Ii; Ii

Uniprot Description

CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 18 E1|18 34.41 cM

Cellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; integral to plasma membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuole

Molecular Function: beta-amyloid binding; CD4 receptor binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; protein binding

Biological Process: activation of MAPK activity; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of innate immune response; positive regulation of kinase activity; positive regulation of MAPKKK cascade; positive regulation of monocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive regulation of transcription, DNA-dependent; positive regulation of virion penetration into host cell; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; protein heterotetramerization; signal transduction