Cd47 recombinant protein

Recombinant Mouse Cd47 protein, C-His Tag

Cat. Num. AAA157996

• Gene Names: Cd47; IAP; Itgp; AA407862; AI848868; AW108519; 9130415E20Rik; B430305P08Rik
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Cd47; Recombinant Mouse Cd47 protein; C-His Tag; IAP; CD47; Cd47 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Mouse
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
• Construction: A DNA sequence encoding the Mouse Cd47 (Met1~Ile162?isoform2) was fused with the C-terminal His Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

Product Categories/Family for Cd47 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 6754382
• NCBI GeneID: 16423
• NCBI Accession #: NP_034711.1
• NCBI GenBank Nucleotide #: NM_010581.3
• UniProt Accession #: Q61735; Q921Z2
• Molecular Weight: 33,098 Da
• NCBI Official Full Name: leukocyte surface antigen CD47
• NCBI Official Synonym Full Names: CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
• NCBI Official Symbol: Cd47
• NCBI Official Synonym Symbols: IAP; Itgp; AA407862; AI848868; AW108519; 9130415E20Rik; B430305P08Rik
• NCBI Protein Information: leukocyte surface antigen CD47; Rh-related antigen; integrin-associated protein
• UniProt Protein Name: Leukocyte surface antigen CD47
• Protein Family: Leukocyte surface antigen
• UniProt Gene Name: Cd47
• UniProt Synonym Gene Names: IAP
• UniProt Entry Name: CD47_MOUSE

Uniprot Description

CD47: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: cell migration; response to bacterium; positive regulation of phagocytosis; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; opsonization; positive regulation of T cell activation; signal transduction; cell adhesion; positive regulation of inflammatory response