Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human Melanoma stained with Tyrosinase Monoclonal Antibody (SPM360).)
Mouse Tyrosinase Monoclonal Antibody | anti-TYR antibody
Tyrosinase (Melanoma Marker) Mouse Monoclonal Antibody
Immunofluorescence (1-2ug/ml)
Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 7.5-8.5,for 10-20 ming followed by cooling at RT for 20 min).
Optimal dilution for a specific application should be determined.
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human Melanoma stained with Tyrosinase Monoclonal Antibody (SPM360).)
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human Melanoma stained with Tyrosinase Monoclonal Antibody (SPM360).)
NCBI and Uniprot Product Information
NCBI Description
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
Uniprot Description
TYR: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.18.1; Oxidoreductase; Amino Acid Metabolism - tyrosine; Membrane protein, integral; Cofactor and Vitamin Metabolism - riboflavin
Chromosomal Location of Human Ortholog: 11q14.3
Cellular Component: cytoplasm; Golgi-associated vesicle; lysosome; melanosome; melanosome membrane; perinuclear region of cytoplasm
Molecular Function: copper ion binding; monooxygenase activity; monophenol monooxygenase activity; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: eye pigment biosynthetic process; melanin biosynthetic process; melanin biosynthetic process from tyrosine; visual perception
Disease: Albinism, Ocular, With Sensorineural Deafness; Albinism, Oculocutaneous, Type Ia; Albinism, Oculocutaneous, Type Ib; Skin/hair/eye Pigmentation, Variation In, 3
Research Articles on TYR
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Product Notes
The TYR tyr (Catalog #AAA438285) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Tyrosinase (Melanoma Marker) Mouse Monoclonal Antibody reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's Tyrosinase can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin. Flow Cytometry (0.5-1ug/million cells ) Immunofluorescence (1-2ug/ml) Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 7.5-8.5,for 10-20 ming followed by cooling at RT for 20 min). Optimal dilution for a specific application should be determined. Researchers should empirically determine the suitability of the TYR tyr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tyrosinase, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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