IAP/OA3/CD47 recombinant protein

Recombinant Mouse IAP/OA3/CD47 Protein (C-6His)

Cat. Num. AAA2553517

• Gene Names: Cd47; IAP; Itgp; AA407862; AI848868; AW108519; 9130415E20Rik; B430305P08Rik
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: IAP/OA3/CD47; Recombinant Mouse IAP/OA3/CD47 Protein (C-6His); Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6; IAP/OA3/CD47 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Gln19-Pro158
• Sequence Length: 324

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IAP/OA3/CD47 recombinant protein

CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig-like domain, five membrane-spanning regions with short intervening loops, and C-terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA, it binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cellcell adhesion, it enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. It may play a role in membrane transport and/or integrin dependent signal transduction. It also prevents premature elimination of red blood cells.

NCBI and Uniprot Product Information

• NCBI GI #: 6754382
• NCBI GeneID: 16423
• NCBI Accession #: NP_034711.1
• NCBI GenBank Nucleotide #: NM_010581.3
• UniProt Accession #: Q61735; Q921Z2
• Molecular Weight: Molecular Mass: 16.7 kDa; Actual Protein Molecular Mass: 30-60 kDa
• NCBI Official Full Name: leukocyte surface antigen CD47
• NCBI Official Synonym Full Names: CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
• NCBI Official Symbol: Cd47
• NCBI Official Synonym Symbols: IAP; Itgp; AA407862; AI848868; AW108519; 9130415E20Rik; B430305P08Rik
• NCBI Protein Information: leukocyte surface antigen CD47
• UniProt Protein Name: Leukocyte surface antigen CD47
• UniProt Gene Name: Cd47
• UniProt Synonym Gene Names: IAP

Uniprot Description

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection ().