CCL4 recombinant protein

CCL4 Protein, Rat, Recombinant (His Tag)

Cat. Num. AAA8123337

• Gene Names: Ccl4; Scya4; Mip1-b
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CCL4; CCL4 Protein; Rat; Recombinant (His Tag); Rat CCL4/MIP1B Protein(His Tag); chemokine (C-C motif) ligand 4; CCL4 recombinant protein

• Host: Yeast
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 30% CAN, 0.1% TFA. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ala24-Asn92

• Species: Rat
• Predicted N Terminal: Ala 24
• Tag: C-His
• Protein Construction: A DNA sequence encoding the rat Ccl4 (NP_446310.1)(Ala24-Asn92) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CCL4 recombinant protein

Background: CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. In particular, higher serum CCL4 levels in patients with oral squamous cell carcinoma (OSCC) are associated with a more advanced stage of disease. CCL4 may be a new molecular therapeutic target for inhibition of lymphangiogenesis and metastasis in OSCC. CCL3 and CCL4 loci may be marker SNPs for risk of HCV treatment outcome. CCL4 can enhance the recruitment of preosteoclasts to bone in the early stage, and the reduction of CCR5 promotes osteoclastogenesis when RANKL is prevalent.

Product Categories/Family for CCL4 recombinant protein

Neuroinflammation

NCBI and Uniprot Product Information

• NCBI GI #: 25742843
• NCBI GeneID: 116637
• NCBI Accession #: NP_446310.1
• NCBI GenBank Nucleotide #: NM_053858.1
• UniProt Accession #: P50230; A1EC89
• Molecular Weight: 10,234 Da
• NCBI Official Full Name: C-C motif chemokine 4
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 4
• NCBI Official Symbol: Ccl4
• NCBI Official Synonym Symbols: Scya4; Mip1-b
• NCBI Protein Information: C-C motif chemokine 4; MIP-1-beta; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1 beta; small inducible cytokine A4; small-inducible cytokine A4
• UniProt Protein Name: C-C motif chemokine 4
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl4
• UniProt Synonym Gene Names: Mip1b; Scya4; MIP-1-beta
• UniProt Entry Name: CCL4_RAT

NCBI Description

a cytokine that is up-regulated during the inflammatory response; may be involved in intrapulmonary recruitment of neutrophils [RGD, Feb 2006]

Uniprot Description

Monokine with inflammatory and chemokinetic properties.