Western Blot (WB)
Rabbit Thromboxane synthase Polyclonal Antibody | anti-TBXAS1 antibody
Thromboxane synthase Antibody
Western Blot (WB)
Western Blot (WB)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Description
Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.
Cofactor: Heme group.
Subunit structure: Monomer.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.12.
Tissue specificity: Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.
Involvement in disease: Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]: Rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.19Thromboxane synthetase deficiency has been detected in some patients with a bleeding disorder due to platelet dysfunction.
Sequence similarities: Belongs to the cytochrome P450 family.
Caution: It is uncertain whether Met-1 is the initiator. An alternative upstream Met is found in primates, but not in other mammals.
Sequence caution: The sequence AAC01761.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC01761.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99269.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99270.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99271.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99272.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99273.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99274.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99275.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99276.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99277.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99278.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF99279.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH41157.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on TBXAS1
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Product Notes
The TBXAS1 tbxas1 (Catalog #AAA415470) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Thromboxane synthase Antibody reacts with Human, Murine (predicted), Porcine (predicted), Rat (predicted). and may cross-react with other species as described in the data sheet. AAA Biotech's Thromboxane synthase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TBXAS1 tbxas1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thromboxane synthase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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