Canine Dual oxidase 1 (DUOX1) ELISA Kit | DUOX1 elisa kit

Canine Dual oxidase 1 (DUOX1) ELISA Kit

Cat. Num. AAA7200983

• Gene Names: DUOX1; LNOX1; THOX1; NOXEF1
• Reactivity: Canine
• Synonyms: Dual oxidase 1 (DUOX1); Canine Dual oxidase 1 (DUOX1) ELISA Kit; DUOX1 elisa kit

• Reactivity: Canine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 28872751
• NCBI GeneID: 53905
• NCBI Accession #: NP_787954.1
• NCBI GenBank Nucleotide #: NM_175940.2
• Molecular Weight: 137,604 Da
• NCBI Official Full Name: dual oxidase 1
• NCBI Official Synonym Full Names: dual oxidase 1
• NCBI Official Symbol: DUOX1
• NCBI Official Synonym Symbols: LNOX1; THOX1; NOXEF1
• NCBI Protein Information: dual oxidase 1; long NOX 1; large NOX 1; thyroid oxidase 1; NADPH thyroid oxidase 1; flavoprotein NADPH oxidase; nicotinamide adenine dinucleotide phosphate oxidase
• UniProt Protein Name: Dual oxidase 1
• Protein Family: Dual oxidase
• UniProt Gene Name: DUOX1
• UniProt Synonym Gene Names: DUOX; LNOX1; THOX1
• UniProt Entry Name: DUOX1_HUMAN

NCBI Description

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

DUOX1: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.6.3.1; Oxidoreductase; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q15.3

Cellular Component: apical plasma membrane; integral to membrane

Molecular Function: peroxidase activity; NAD(P)H oxidase activity; heme binding; calcium ion binding; NADP binding

Biological Process: cuticle development; response to cAMP; hydrogen peroxide catabolic process; cytokine and chemokine mediated signaling pathway; thyroid hormone generation; hormone biosynthetic process; response to oxidative stress; superoxide release; hydrogen peroxide biosynthetic process