Rabbit anti-Human, Mouse VNN1 Polyclonal Antibody | anti-VNN1 antibody

VNN1 Rabbit Polyclonal

Cat. Num. AAA7605654

• Gene Names: VNN1; HDLCQ8; Tiff66
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: VNN1; Polyclonal Antibody; VNN1 Rabbit Polyclonal; anti-VNN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 513

• Applicable Applications for anti-VNN1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Vanin 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas cancer slide using MBS7605654 (VNN1 Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS7605654 (VNN1 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 4128047
• NCBI GeneID: 8876
• UniProt Accession #: O95497; Q4JFW6; Q4VAS7; Q4VAS8; Q4VAS9; Q9UF16; Q9UJF4; A8K310
• Molecular Weight: 57,012 Da
• NCBI Official Full Name: VNN1 protein
• NCBI Official Synonym Full Names: vanin 1
• NCBI Official Symbol: VNN1
• NCBI Official Synonym Symbols: HDLCQ8; Tiff66
• NCBI Protein Information: pantetheinase
• UniProt Protein Name: Pantetheinase
• Protein Family: Pantetheinase
• UniProt Gene Name: VNN1
• UniProt Synonym Gene Names: Vanin-1
• UniProt Entry Name: VNN1_HUMAN

NCBI Description

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

Uniprot Description

VNN1: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Belongs to the CN hydrolase family. BTD/VNN subfamily.

Protein type: Cell adhesion; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, GPI anchor; EC 3.5.1.92; Hydrolase

Chromosomal Location of Human Ortholog: 6q23-q24

Cellular Component: integral to membrane; plasma membrane

Molecular Function: pantetheine hydrolase activity

Biological Process: acute inflammatory response; biotin metabolic process; cell motility; cell-cell adhesion; central nervous system development; chronic inflammatory response; inflammatory response; innate immune response; pantothenate metabolic process; positive regulation of T cell differentiation in the thymus; response to oxidative stress