C1D recombinant protein

Recombinant Human C1D

Cat. Num. AAA145742

• Gene Names: C1D; LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• Purity: Greater than 85% as determined by SDS-PAGE.
• Synonyms: C1D; Recombinant Human C1D; C1D Human; C1D Human Recombinant; hC1D; LRP1; SUN-CoR; SUNCOR; Nuclear nucleic acid-binding protein C1D; C1D recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% as determined by SDS-PAGE.
• Form/Format: The C1D solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAGEEIN EDYPVEIHEY LSAFENSIGA VDEMLKTMMS VSRNELLQKL DPLEQAKVDL VSAYTLNSMF WVYLATQGVN PKEHPVKQEL ERIRVYMNRV KEITDKKKAG KLDRGAASRF VKNALWEPKS KNASKVANKG KSKS
• Sequence Length: 141

Related Product Information for C1D recombinant protein

Description: C1D Human Recombinant produced in E Coli is a single polypeptide chain containing 164 amino acids (1-141) and having a molecular mass of 18.4kDa. C1D is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: C1D s which regulates TRAX/Translin complex formation takes part in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA. C1D which activates PRKDC in the presence of linear DNA and supercoiled DNA also induces apoptosis in a p53/TP53 dependent manner.

Product Categories/Family for C1D recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 298231253
• NCBI GeneID: 10438
• NCBI Accession #: NP_001177192.1
• NCBI GenBank Nucleotide #: NM_001190263.1
• UniProt Accession #: Q13901; Q05D64; A8K336; D6W5F8
• Molecular Weight: 16,019 Da
• NCBI Official Full Name: nuclear nucleic acid-binding protein C1D
• NCBI Official Synonym Full Names: C1D nuclear receptor corepressor
• NCBI Official Symbol: C1D
• NCBI Official Synonym Symbols: LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• NCBI Protein Information: nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; C1D nuclear receptor co-repressor; nuclear DNA-binding protein; small unique nuclear receptor co-repressor; small unique nuclear receptor corepressor
• UniProt Protein Name: Nuclear nucleic acid-binding protein C1D
• Protein Family: Nuclear nucleic acid-binding protein
• UniProt Gene Name: C1D
• UniProt Synonym Gene Names: hC1D
• UniProt Entry Name: C1D_HUMAN

NCBI Description

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Uniprot Description

C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family.

Protein type: Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2p13-p12

Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex)

Molecular Function: ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity

Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent