VAMP8 blocking peptide

VAMP8 Blocking Peptide (N-term)

• Gene Names: VAMP8; EDB; VAMP-8
• Synonyms: VAMP8; VAMP8 Blocking Peptide (N-term); Vesicle-associated membrane protein 8; VAMP-8; Endobrevin; EDB; VAMP8 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 2-16 of Human VAMP8
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 100

• Cellular Location: Lysosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein Note: Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity).
• Tissue Location: Platelets.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VAMP8 blocking peptide

SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes.

NCBI and Uniprot Product Information

• NCBI GI #: 55976764
• NCBI GeneID: 8673
• UniProt Accession #: Q9BV40; O60625; Q53SP9; Q6IB09
• Molecular Weight: 11,438 Da
• NCBI Official Full Name: Vesicle-associated membrane protein 8
• NCBI Official Synonym Full Names: vesicle associated membrane protein 8
• NCBI Official Symbol: VAMP8
• NCBI Official Synonym Symbols: EDB; VAMP-8
• NCBI Protein Information: vesicle-associated membrane protein 8
• UniProt Protein Name: Vesicle-associated membrane protein 8
• Protein Family: Vesicle-associated membrane protein
• UniProt Gene Name: VAMP8
• UniProt Synonym Gene Names: EDB
• UniProt Entry Name: VAMP8_HUMAN

NCBI Description

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

Uniprot Description

VAMP8: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 2p12-p11.2

Cellular Component: cytoplasm; cytosol; early endosome; late endosome membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome; secretory granule membrane; SNARE complex; vesicle

Molecular Function: chloride channel inhibitor activity; protein binding; SNAP receptor activity; SNARE binding

Biological Process: entry of virus into host cell; eosinophil degranulation; neutrophil degranulation; post-Golgi vesicle-mediated transport; vesicle fusion