Rabbit anti-Human, Mouse FXR2 Polyclonal Antibody | anti-FXR2 antibody

FXR2 Antibody

Cat. Num. AAA9404596

• Gene Names: FXR2; FXR2P; FMR1L2
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: FXR2; Polyclonal Antibody; FXR2 Antibody; Fragile X mental; retardation syndrome; related protein 2; anti-FXR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total FXR2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 673

• Applicable Applications for anti-FXR2 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500~1:3000; Immunohistochemistry: 1:50~1:100; Immunofluorescence: 1:100~1:500
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human FXR2.
• Target Name: FXR2
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from COLO205 cells, using FXR2 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using FXR2 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of A549 cells, using FXR2 antibody.)

Related Product Information for anti-FXR2 antibody

RNA-binding protein.Wiley S.R., Immunity 3:673-682(1995).Pitti R.M., J. Biol. Chem. 271:12687-12690(1996).Hymowitz S.G., Mol. Cell 4:563-571(1999).

Product Categories/Family for anti-FXR2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 259013556
• NCBI GeneID: 9513
• NCBI Accession #: NP_004851.2
• NCBI GenBank Nucleotide #: NM_004860.3
• UniProt Accession #: P51116; Q86V09; Q8WUM2; B2R9M2; D3DTQ1
• Molecular Weight: 74,223 Da
• NCBI Official Full Name: fragile X mental retardation syndrome-related protein 2
• NCBI Official Synonym Full Names: fragile X mental retardation, autosomal homolog 2
• NCBI Official Symbol: FXR2
• NCBI Official Synonym Symbols: FXR2P; FMR1L2
• NCBI Protein Information: fragile X mental retardation syndrome-related protein 2
• UniProt Protein Name: Fragile X mental retardation syndrome-related protein 2
• Protein Family: Fragile X mental retardation syndrome-related protein
• UniProt Gene Name: FXR2
• UniProt Synonym Gene Names: FMR1L2
• UniProt Entry Name: FXR2_HUMAN

NCBI Description

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008]

Uniprot Description

FXR2: RNA-binding protein. Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. Belongs to the FMR1 family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: polysome; membrane; cytoplasm; nucleus

Molecular Function: mRNA binding; identical protein binding; protein binding; RNA binding

Biological Process: negative regulation of translation