TRPV1 blocking peptide

TRPV1 Antibody (N-term) Blocking peptide

• Gene Names: TRPV1; VR1
• Synonyms: TRPV1; TRPV1 Antibody (N-term) Blocking peptide; Transient receptor potential cation channel subfamily V member 1; TrpV1; Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1; VR1; TRPV1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of TRPV1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 839

• Cellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Cell projection, dendritic spine membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: Mostly, but not exclusively expressed in postsynaptic dendritic spines.
• Tissue Location: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TRPV1 blocking peptide

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12- hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH

NCBI and Uniprot Product Information

• NCBI GI #: 296452849
• NCBI GeneID: 7442
• UniProt Accession #: Q8NER1; Q3LU47; Q9H0G9; Q9H303; Q9H304; Q9NQ74; Q9NY22; A2RUA9
• Molecular Weight: 94,211 Da
• NCBI Official Full Name: Transient receptor potential cation channel subfamily V member 1
• NCBI Official Synonym Full Names: transient receptor potential cation channel subfamily V member 1
• NCBI Official Symbol: TRPV1
• NCBI Official Synonym Symbols: VR1
• NCBI Protein Information: transient receptor potential cation channel subfamily V member 1
• UniProt Protein Name: Transient receptor potential cation channel subfamily V member 1
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPV1
• UniProt Synonym Gene Names: VR1; TrpV1; OTRPC1
• UniProt Entry Name: TRPV1_HUMAN

NCBI Description

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TRPV1: a receptor for capsaicin and a non-selective cation channel that is structurally related to members of the TRP family of ion channels. Activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.

Protein type: Channel, cation; Membrane protein, multi-pass; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane; postsynaptic membrane

Molecular Function: ATP binding; calcium channel activity; calcium-release channel activity; excitatory extracellular ligand-gated ion channel activity; phosphoprotein binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; chemosensory behavior; thermoception; transport