Rabbit anti-Human OPCML Polyclonal Antibody | anti-OPCML antibody

OPCML, ID (OPCML, IGLON1, OBCAM, Opioid-binding protein/cell adhesion molecule, IgLON family member 1) (PE)

Cat. Num. AAA6327831

• Gene Names: OPCML; OPCM; OBCAM; IGLON1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: OPCML; Polyclonal Antibody; ID (OPCML; IGLON1; OBCAM; Opioid-binding protein/cell adhesion molecule; IgLON family member 1) (PE); IgLON family member 1; anti-OPCML antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-OPCML antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: OPCML antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human OPCML.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(OPCML Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the OPCML antibody detected the OPCML protein (arrow).)

Related Product Information for anti-OPCML antibody

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-OPCML antibody

Antibodies; Cell Markers

References

Bailey, S.D., et al. Diabetes Care (2010). In press: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Stolk, L., et al. Nat. Genet. (2009). In press: Cui, Y., et al. PLoS ONE 3 (8), E2990 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 4505505
• NCBI GeneID: 4978
• NCBI Accession #: NP_002536.1
• NCBI GenBank Nucleotide #: NM_002545.4
• UniProt Accession #: Q14982; Q17RN7; Q7Z3W6; B2CZX2; B7ZLQ1
• Molecular Weight: 38,849 Da
• NCBI Official Full Name: opioid-binding protein/cell adhesion molecule isoform a preproprotein
• NCBI Official Synonym Full Names: opioid binding protein/cell adhesion molecule-like
• NCBI Official Symbol: OPCML
• NCBI Official Synonym Symbols: OPCM; OBCAM; IGLON1
• NCBI Protein Information: opioid-binding protein/cell adhesion molecule
• UniProt Protein Name: Opioid-binding protein/cell adhesion molecule
• Protein Family: Opioid-binding protein/cell adhesion molecule
• UniProt Gene Name: OPCML
• UniProt Synonym Gene Names: IGLON1; OBCAM; OBCAM; OPCML; Opioid-binding cell adhesion molecule
• UniProt Entry Name: OPCM_HUMAN

NCBI Description

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

OPCML: Binds opioids in the presence of acidic lipids; probably involved in cell contact. Defects in OPCML are a cause of susceptibility to ovarian cancer (OC). Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the immunoglobulin superfamily. IgLON family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: neuron projection; cell surface; cell soma; plasma membrane; intercellular junction

Biological Process: cell-cell adhesion; regulation of neurogenesis; neuron recognition; cell adhesion

Disease: Ovarian Cancer