SUPT6H blocking peptide
SUPT6H Antibody (N-term) Blocking Peptide
Gene Names
SUPT6H; SPT6; SPT6H; emb-5
Synonyms
SUPT6H; SUPT6H Antibody (N-term) Blocking Peptide; Transcription elongation factor SPT6; hSPT6; Histone chaperone suppressor of Ty6; Tat-cotransactivator 2 protein; Tat-CT2 protein; KIAA0162; SPT6H; SUPT6H blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1726
Cellular Location
Nucleus.
Tissue Location
Ubiquitously expressed.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for SUPT6H blocking peptide
Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
84,632 Da
NCBI Official Full Name
Transcription elongation factor SPT6
NCBI Official Synonym Full Names
SPT6 homolog, histone chaperone
NCBI Official Symbol
SUPT6H
NCBI Official Synonym Symbols
SPT6; SPT6H; emb-5
NCBI Protein Information
transcription elongation factor SPT6
UniProt Protein Name
Transcription elongation factor SPT6
UniProt Gene Name
SUPT6H
UniProt Synonym Gene Names
KIAA0162; SPT6H; hSPT6; Tat-CT2 protein
UniProt Entry Name
SPT6H_HUMAN
Uniprot Description
SPT6: promotes transcription elongation of many genes. A histone H3 chaperone that may alter chromatin structure during transcription. Binds RNA polymerase II (RNAPII) phosphorylated on Ser2 through its primitive SH2 domain, which appears to recognize phosphoserine rather than phosphotyrosine motifs. Associates with the nuclear mRNA export factor, THOC4.
Protein type: Nuclear receptor co-regulator; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q11.2
Molecular Function: histone binding; protein binding; transcription factor activity
Biological Process: positive regulation of RNA elongation from RNA polymerase II promoter; regulation of isotype switching; regulation of mRNA processing; regulation of muscle cell differentiation
Research Articles on SUPT6H
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Product Notes
The SUPT6H supt6h (Catalog #AAA9221810) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SUPT6H, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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