Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS7611838(SUPT6H antibody) at dilution of 1:100)
Rabbit anti-Human SUPT6H Polyclonal Antibody | anti-SUPT6H antibody
anti-SUPT6H antibody
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
>=95% as determined by SDS-PAGE. Immunogen affinity purified
Synonyms
SUPT6H; Polyclonal Antibody; anti-SUPT6H antibody; KIAA0162; SPT6H
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>=95% as determined by SDS-PAGE. Immunogen affinity purified
Form/Format
Liquid. PBS with 0.02% sodium azide and 50% glycerol pH7.3
Applicable Applications for anti-SUPT6H antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:200
Immunogen
suppressor of Ty 6 homolog(S. cerevisiae)
Preparation and Storage
Store at -20 degree C for 12 months. Avoid repeated freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS7611838(SUPT6H antibody) at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS7611838(SUPT6H antibody) at dilution of 1:100)
Related Product Information for anti-SUPT6H antibody
Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II(RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase(AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.
Product Categories/Family for anti-SUPT6H antibody
NCBI and Uniprot Product Information
Similar Products
Product Notes
The SUPT6H supt6h (Catalog #AAA7611838) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The anti-SUPT6H antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SUPT6H can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the SUPT6H supt6h for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SUPT6H, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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