STMN2 blocking peptide

STMN2 Blocking Peptide (N-term)

• Gene Names: STMN2; SCG10; SCGN10
• Synonyms: STMN2; STMN2 Blocking Peptide (N-term); Stathmin-2; Superior cervical ganglion-10 protein; Protein SCG10; SCG10; SCGN10; STMN2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 36-49 of HUMAN STMN2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 179

• Cellular Location: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium Note: Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.
• Tissue Location: Neuron specific.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for STMN2 blocking peptide

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 51704330
• NCBI GeneID: 11075
• UniProt Accession #: Q93045; O14952; Q6PK68; A8K9M2; G3V110
• Molecular Weight: 21,802 Da
• NCBI Official Full Name: Stathmin-2
• NCBI Official Synonym Full Names: stathmin 2
• NCBI Official Symbol: STMN2
• NCBI Official Synonym Symbols: SCG10; SCGN10
• NCBI Protein Information: stathmin-2
• UniProt Protein Name: Stathmin-2
• Protein Family: Stathmin
• UniProt Gene Name: STMN2
• UniProt Synonym Gene Names: SCG10; SCGN10; Protein SCG10
• UniProt Entry Name: STMN2_HUMAN

NCBI Description

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Uniprot Description

STMN2: a cytoskeletal protein that may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Neuron specific.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: cell soma; cytoplasm; growth cone; lamellipodium; neuron projection; perinuclear region of cytoplasm

Molecular Function: calcium-dependent protein binding; protein binding; tubulin binding

Biological Process: negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization; positive regulation of microtubule depolymerization