SCN1B blocking peptide

SCN1B Antibody (N-Term) Blocking Peptide

• Gene Names: SCN1B; ATFB13; BRGDA5; GEFSP1
• Synonyms: SCN1B; SCN1B Antibody (N-Term) Blocking Peptide; Sodium channel subunit beta-1; SCN1B blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 268

• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SCN1B blocking peptide

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

NCBI and Uniprot Product Information

• NCBI GI #: 39930610
• NCBI GeneID: 6324
• NCBI Accession #: NP_950238.1
• NCBI GenBank Nucleotide #: NM_199037.4
• UniProt Accession #: Q07699; Q5TZZ4; Q6TN97
• Molecular Weight: 30,440 Da
• NCBI Official Full Name: sodium channel subunit beta-1 isoform b
• NCBI Official Synonym Full Names: sodium voltage-gated channel beta subunit 1
• NCBI Official Symbol: SCN1B
• NCBI Official Synonym Symbols: ATFB13; BRGDA5; GEFSP1
• NCBI Protein Information: sodium channel subunit beta-1
• UniProt Protein Name: Sodium channel subunit beta-1
• Protein Family: Sodium channel
• UniProt Gene Name: SCN1B
• UniProt Entry Name: SCN1B_HUMAN

NCBI Description

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Description

SCN1B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in SCN1B are the cause of Brugada syndrome type 5 (BRGDA5). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, sodium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: plasma membrane; T-tubule; voltage-gated sodium channel complex

Molecular Function: sodium channel inhibitor activity; sodium channel regulator activity; voltage-gated sodium channel activity

Biological Process: action potential propagation; axon guidance; cardiac muscle contraction; corticospinal neuron axon guidance; locomotion; membrane depolarization; synaptic transmission

Disease: Atrial Fibrillation, Familial, 13; Brugada Syndrome 5; Generalized Epilepsy With Febrile Seizures Plus, Type 1